Schistosoma mansoni: immunodepression of hepatic schistosome granuloma formation in mice infected by Trypanosoma cruzi

Genaro, O.; Brener, Z.; Coelho, P.M.Z.

doi:10.1590/S0037-86821986000100008

Abstracts

Infection by Trypanosoma cruzi in mice depresses hepatic granuloma formation around Schistosoma mansoni eggs. This immunodepressive effect occurred in mice with Chagas' disease at the acute and/or chronic phases, granulomas being signijicantly smaller than those in Controls. Data suggest that Chagas ' disease depresses the delayed hypersensitivity immune response directly.

Schistosoma mansoni; Immunodepression; Granuloma; Trypanosoma cruzi

A infecção de camundongos pelo Trypanosoma cruzi inibe a formação do granuloma hepático esquistossomótico. Este efeito imunodepressor ocorreu em camundongos com a fase aguda ou crônica da doença de Chagas, sendo os granulomas significativamente menores que nos animais controles. Os dados sugerem que a doença de Chagas deprime diretamente a imunidade celular.

Schistosoma mansoni; Imunodepressão; Granuloma; Trypanosoma cruzi

ARTICLES

Schistosoma mansoni: immunodepression of hepatic schistosome granuloma formation in mice infected by Trypanosoma cruzi^*

O. Genaro^I; Z. Brener^II; P.M.Z. Coelho^III

^IDepartamento de Patologia Tropical/INPA, Manaus

^IICentro de Pesquisas René Rachou, FIOCRUZ, Belo Horizonte

^IIIDepartamento de Parasitologia, ICB/UFMG, Belo Horizonte

^{Adress to correspondence} Endereço para correspondência: Prof? Paulo Marcos Z. Coelho Departamento de Parasitologia ICB/UFMG Caixa Postal 2486 30000 Belo Horizonte, MG.

ABSTRACT

Infection by Trypanosoma cruzi in mice depresses hepatic granuloma formation around Schistosoma mansoni eggs. This immunodepressive effect occurred in mice with Chagas' disease at the acute and/or chronic phases, granulomas being signijicantly smaller than those in Controls. Data suggest that Chagas ' disease depresses the delayed hypersensitivity immune response directly.

Keywords:Schistosoma mansoni. Immunodepression. Granuloma. Trypanosoma cruzi.

RESUMO

A infecção de camundongos pelo Trypanosoma cruzi inibe a formação do granuloma hepático esquistossomótico. Este efeito imunodepressor ocorreu em camundongos com a fase aguda ou crônica da doença de Chagas, sendo os granulomas significativamente menores que nos animais controles. Os dados sugerem que a doença de Chagas deprime diretamente a imunidade celular.

Palavras-chave:Schistosoma mansoni. Imunodepressão. Granuloma. Trypanosoma cruzi.

Full text available only in PDF format.

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Recebido para publicação em 26/6/1985.

References

1. Abdel-Wahab MF, Powers KG, Mahmoud SS, Good WC. Suppression of schistosome granuloma formation by malaria in mice. American Journal of Tropical Medicine and Hygiene 23:915-918, 1974.
2. Boros DL, Warren KS. Effect of anti-macrophage serum on hypersensitivity (Schistosoma mansoni eggs) and foreign body (Divinylbenzene copoliner bead) granuloma. Journal of Immunology 107:534-539, 1971.
3. Brener Z, Chiari E. Observações sobre a fase crônica da doença de Chagas experimental no camundongo. Revista do Instituto de Medicina Tropical de São Paulo 5: 128- 132, 1963.
4. Brener Z, Chiari E. Variações morfológicas observadas em diferentes amostras de Trypanosoma cruzi Revista do Instituto de Medicina Tropical de São Paulo 5: 220- 224, 1963.
5. Clinton BA, Ortiz-Ortiz L, Garcia W, Martinez T, Capin R. Trypanosoma cruzi: Early immune responses in infected mice. Experimental Parasitology 37: 417- 425, 1975.
6. Corsini AC, Costa MG. Immunosuppression in mice infected with Trypanosoma cruzi (Chagas, 1909). I. Evidence of polyclonal B cell activation in experimental infections mimiced by an extract prepared from circulating trypomastigotes. Revista do Instituto de Medicina Tropical de São Paulo 23:114-121, 1981.
7. Costa MC. Imunossupressão na infecçào pelo Trypanosoma cruzi (Chagas, 1909): I. Efeitos dos extratos de epimastigotas e tripomastigotas sobre a resposta imune em camundongos. Tese de Doutorado. Unicamp. Campinas. 1982.
8. CunninghamDS, BenavidesGR, Kuhn RE. Suppression of mitogen-induced blastogenesis by the Trypanosoma cruzi-induced suppressor substance. The Journal of Parasitology 66: 722-729, 1980.
9. Domingo EO, Warren KS. The inhibition of granuloma formation around Schistosoma mansoni eggs. II. Thymectomy. The American Journal of Pathology 5 1: 757- 767, 1967.
10. Domingo EO, Warren KS. The inhibition of granuloma formation around Schistosoma mansoni eggs. III. Heterologous antilymphocyte serum. The American Journal of Pathology 52: 613-631, 1968.
11. Domingo EO, Cowan RBT, Warren KS. The inhibition of granuloma formation around Schistosoma mansoni eggs. I. Immunosuppressive drugs. The American Journal of Tropical Medicine and Hygiene 16: 284-292, 1967.
12. Federici EE, Albermann WB, Neva FA. Chronic and Progressive myocarditis and myositis in C₃H mice infected with Trypanosoma cruzi The American Journal of Tropical Medicine and Hygiene 13: 273-280, 1964.
13. Freitas JR. Ritmo de crescimento de Biomphalaria glabrata (Say, 1818). Padronização da técnica de criação. Tese de doutorado. Universidade Federal de Minas Gerais, Belo Horizonte, 1973.
14. Machnicka B, Choromawski L. The influence of immunosuppression generatcd by Trypanosoma cruzi on the development of Hymenolepis diminuta in CFW mice. Bulletin de 1'Academie Polonaise de Science. 17: 739- 748. 1979.
15. Mahmoud AAF, Strickland GT, Warren KS. Toxoplasmosis and the host-parasite relationship in murine Schistosomiasis mansoni Journal of Infectious Diseases 135:408-413, 1977.
16. Pellegrino J, Katz N. Experimental chemotherapy of Schistosomiasis mansoni In: Dawes B (ed) Advances in Parasitology, Academic Press, London, p. 233-290, 1968.
17. Ramos C, Lamoyi E, Feoli M, Rodrigues M, Perez M, Ortiz-Ortiz L. Trypanosoma cruzi: immunosuppressed response to different antigens in the infected mouse. Experimental Parasitology 45: 19-199, 1978.
18. Rced SE. Larson CL. Speer CA. Suppression of cell mediated immunity in experimental Chagas' disease. Zeitschrift fur Parasitenkunde 52: 1 1-17. 1977.
19. Rowland EC, Kuhn RE. Suppression of cellular responses in mice during Trypanosoma cruzi infection. Infection and Immunity 20: 393-397. 1978.
20. Silva LHP, Nussenzweig V. Sobre uma cepa de Trypanosoma cruzi altamente virulenta para o camundongo branco. Folia Clinica et Biologica 20: 191-207, 1953.
21. Teixeira ARL. Competência imunológica do paciente chagásico. Imunodepressão na forma aguda inaparente. Autoimunidade no hospedeiro imunizado. Tese de Doutorado. Universidade Federal de Minas Gerais. Belo Horizonte. 1981.
22. Teixeira ARL, Teixeira G, Macedo J, Prata A. Acquired cell-mediated immunodepression in acute Chagas" disease. Journal of Clinical Investigation 62: 1132- 1141, 1978.
23. Warren KS. Inhibition of granuloma formation around Schistosoma mansoni eggs. The American Journal of Pathology 56:293-303, 1969.
24. Warren KS, Domingo EO, Cowan RBT. Granuloma formation around schistosome eggs as a manifestation of delayed hypersensitivity. The American Journal of Pathology 51: 735-756. 1967.

Endereço para correspondência:

Prof? Paulo Marcos Z. Coelho

Departamento de Parasitologia

ICB/UFMG

Caixa Postal 2486

30000 Belo

Horizonte, MG.

*

This study was supported by CNPq and FINEP, Brazil.

Publication Dates

Publication in this collection
06 June 2013
Date of issue
Mar 1986

History

Accepted
26 June 1985
Received
26 June 1985

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. Abdel-Wahab MF, Powers KG, Mahmoud SS, Good WC. Suppression of schistosome granuloma formation by malaria in mice. American Journal of Tropical Medicine and Hygiene 23:915-918, 1974.

[2] 2. Boros DL, Warren KS. Effect of anti-macrophage serum on hypersensitivity (Schistosoma mansoni eggs) and foreign body (Divinylbenzene copoliner bead) granuloma. Journal of Immunology 107:534-539, 1971.

[3] 3. Brener Z, Chiari E. Observações sobre a fase crônica da doença de Chagas experimental no camundongo. Revista do Instituto de Medicina Tropical de São Paulo 5: 128- 132, 1963.

[4] 4. Brener Z, Chiari E. Variações morfológicas observadas em diferentes amostras de Trypanosoma cruzi Revista do Instituto de Medicina Tropical de São Paulo 5: 220- 224, 1963.

[5] 5. Clinton BA, Ortiz-Ortiz L, Garcia W, Martinez T, Capin R. Trypanosoma cruzi: Early immune responses in infected mice. Experimental Parasitology 37: 417- 425, 1975.

[6] 6. Corsini AC, Costa MG. Immunosuppression in mice infected with Trypanosoma cruzi (Chagas, 1909). I. Evidence of polyclonal B cell activation in experimental infections mimiced by an extract prepared from circulating trypomastigotes. Revista do Instituto de Medicina Tropical de São Paulo 23:114-121, 1981.

[7] 7. Costa MC. Imunossupressão na infecçào pelo Trypanosoma cruzi (Chagas, 1909): I. Efeitos dos extratos de epimastigotas e tripomastigotas sobre a resposta imune em camundongos. Tese de Doutorado. Unicamp. Campinas. 1982.

[8] 8. CunninghamDS, BenavidesGR, Kuhn RE. Suppression of mitogen-induced blastogenesis by the Trypanosoma cruzi-induced suppressor substance. The Journal of Parasitology 66: 722-729, 1980.

[9] 9. Domingo EO, Warren KS. The inhibition of granuloma formation around Schistosoma mansoni eggs. II. Thymectomy. The American Journal of Pathology 5 1: 757- 767, 1967.

[10] 10. Domingo EO, Warren KS. The inhibition of granuloma formation around Schistosoma mansoni eggs. III. Heterologous antilymphocyte serum. The American Journal of Pathology 52: 613-631, 1968.

[11] 11. Domingo EO, Cowan RBT, Warren KS. The inhibition of granuloma formation around Schistosoma mansoni eggs. I. Immunosuppressive drugs. The American Journal of Tropical Medicine and Hygiene 16: 284-292, 1967.

[12] 12. Federici EE, Albermann WB, Neva FA. Chronic and Progressive myocarditis and myositis in C₃H mice infected with Trypanosoma cruzi The American Journal of Tropical Medicine and Hygiene 13: 273-280, 1964.

[13] 13. Freitas JR. Ritmo de crescimento de Biomphalaria glabrata (Say, 1818). Padronização da técnica de criação. Tese de doutorado. Universidade Federal de Minas Gerais, Belo Horizonte, 1973.

[14] 14. Machnicka B, Choromawski L. The influence of immunosuppression generatcd by Trypanosoma cruzi on the development of Hymenolepis diminuta in CFW mice. Bulletin de 1'Academie Polonaise de Science. 17: 739- 748. 1979.

[15] 15. Mahmoud AAF, Strickland GT, Warren KS. Toxoplasmosis and the host-parasite relationship in murine Schistosomiasis mansoni Journal of Infectious Diseases 135:408-413, 1977.

[16] 16. Pellegrino J, Katz N. Experimental chemotherapy of Schistosomiasis mansoni In: Dawes B (ed) Advances in Parasitology, Academic Press, London, p. 233-290, 1968.

[17] 17. Ramos C, Lamoyi E, Feoli M, Rodrigues M, Perez M, Ortiz-Ortiz L. Trypanosoma cruzi: immunosuppressed response to different antigens in the infected mouse. Experimental Parasitology 45: 19-199, 1978.

[18] 18. Rced SE. Larson CL. Speer CA. Suppression of cell mediated immunity in experimental Chagas' disease. Zeitschrift fur Parasitenkunde 52: 1 1-17. 1977.

[19] 19. Rowland EC, Kuhn RE. Suppression of cellular responses in mice during Trypanosoma cruzi infection. Infection and Immunity 20: 393-397. 1978.

[20] 20. Silva LHP, Nussenzweig V. Sobre uma cepa de Trypanosoma cruzi altamente virulenta para o camundongo branco. Folia Clinica et Biologica 20: 191-207, 1953.

[21] 21. Teixeira ARL. Competência imunológica do paciente chagásico. Imunodepressão na forma aguda inaparente. Autoimunidade no hospedeiro imunizado. Tese de Doutorado. Universidade Federal de Minas Gerais. Belo Horizonte. 1981.

[22] 22. Teixeira ARL, Teixeira G, Macedo J, Prata A. Acquired cell-mediated immunodepression in acute Chagas" disease. Journal of Clinical Investigation 62: 1132- 1141, 1978.

[23] 23. Warren KS. Inhibition of granuloma formation around Schistosoma mansoni eggs. The American Journal of Pathology 56:293-303, 1969.

[24] 24. Warren KS, Domingo EO, Cowan RBT. Granuloma formation around schistosome eggs as a manifestation of delayed hypersensitivity. The American Journal of Pathology 51: 735-756. 1967.