Associação do tiabendazol com mebendazol no tratamento das helmintoses intestinais

Prata, A.; Castro, C.; Mello, D.A.

doi:10.1590/S0037-86821981000100012

Resumo

420 patients were treated with a combination of mebendazol (5ml or one tablet equaling 100mg) and thiabendazole (various doses) given twice a day for two to three days. The following indexes of cure were obtained. Approximately 90-95% for Enterobius, Strongyloides, Tricocephalus and Ascaris and between 80-90% for hookworm. These results were in hospitalised patients with a control of cure of four examinations in a month. In outpatients the indices of cure declined related to the degree of vigilance observed in relation to drug taking. Then the dose of thiabendazole is raised to 166mg-250mg in 5ml or 500mg in a tablet the duration of treatment can be reduced to three or two days. However more side effects are observed with this regimen.

Associação do tiabendazol com mebendazol no tratamento das helmintoses intestinais

A. Prata; C. Castro; D.A. Mello

ABSTRACT

420 patients were treated with a combination of mebendazol (5ml or one tablet equaling 100mg) and thiabendazole (various doses) given twice a day for two to three days. The following indexes of cure were obtained. Approximately 90-95% for Enterobius, Strongyloides, Tricocephalus and Ascaris and between 80-90% for hookworm. These results were in hospitalised patients with a control of cure of four examinations in a month. In outpatients the indices of cure declined related to the degree of vigilance observed in relation to drug taking.

Then the dose of thiabendazole is raised to 166mg-250mg in 5ml or 500mg in a tablet the duration of treatment can be reduced to three or two days. However more side effects are observed with this regimen.

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1. AMATO NETO, V., RODRIGUES, M.S.M., PEDRO, R.J. & LUCAS, R.S. Tratamento da ascaridiose e da tricocefalíase por meio de dose única de mebendazole. Rev. Bras. Clínic. Terap. 5:269-272, 1976.
2. BANZON, T.C., SINGSON, C.N. and CROSS, J.H. Mebendazole treatment for intestinal nematodes in a Philippine barrio. J. Philipp Med. Ass. 52: 239-243, 1976. In Trop. Dis. Bull. 74:246, 1977.
3. BRUGMANS, J.P., THIENPONT, C.D., VAN WINJNGAARDEN, I., VANPARYS, O.F., SCHUERMANS, V.L. e LAURVERS, H.L. Mebendazole in anterobiais. Radiochemical and pilot clinicai study in 1278 subjects. Jour. Am. Med. Ass. 217:313-316, 1971.
4. CAMPOS, R., CIMERMAN, B" CASTANHO, R.P., TORRE, M.C.C.D. e CASTILHO, V.L.P. Tratamento de helmintíases intestinais com a associação mebendazol e tiabendazol. Rev. Bras. Clin. Terap. 5: 23-26, 1976.
5. CHAIA, G. e CUNHA, A.S. Terapeutic action of mebendazole (R.17.635) against human helminthiasis. Folha med. 63:843-852, 1971.
6. CHAVARRIA, A.P., SWARTZWELDER, J.C., VILLAREJOS, V.M. e ZELEDÓN, R. Mebendazole, an effective broadspectrum anthelmintic. Am. Jour. Trop. Med. Hyg. 22: 592-595, 1973.
7. COPELMAN, H. 0 mebendazole no tratamento da teníase. XXV Cong. Bras. Gastroenterologia.
8. DAVIS, A. Drug treatment in intestinal helminthiases. World Health Org. 1973.
9. GRAHAN, C.F. A device for the diagnosis of Enterobius infection. Am. Jour. Trop. Med. 21:159-161, 1941.
10. KATZ, N" CHAVES, A. e PELLEGRINO, J. A simple device for quantitative stool thick - smear technique in schistosomiasis mansoni. Rev. Inst. Med. Trop. São Paulo. 14: 397-400, 1972.
11. KATZ, N. e ZICKER, F. Ensaio clínico com mebendazole nas teníases. Rev. Soc. Med. Trop. 7:225-229, 1973.
12. MORAIS, R.G. Contribuição para o estudo do Strongyloides stercoralis e da estrongiloidose no Brasil. Rev. Serviço Esp. Saúde Públ. 1: 507, 1948.
13. SHIRATSUCHI, M.S., LEVI, G.C., AMATO NETO, V., AVI LA, C.A., STEFANl, H.N.V., MOSTERIO, L" TSUKUMO, M.K.K., KONICHI, S.R. e CORREA, L.L. Tratamento da tricococefaliase pelo mebendazole. Resultados obtidos. Rev. Inst. Med. Trop. São Paulo. 17:206-209, 1975.
14. SOUZA, D.W.C., SOUZA, M.S.L. e NEVES, J. Ação terapêutica do mebendazole (R.17.635) em pacientes poliparasitados. Resultados preliminares. Rev. Inst. Med. Trop. São Paulo. 15: 30-33, 1973.

Datas de Publicação

Publicação nesta coleção
10 Jun 2013
Data do Fascículo
Jun 1981

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[1] 1. AMATO NETO, V., RODRIGUES, M.S.M., PEDRO, R.J. & LUCAS, R.S. Tratamento da ascaridiose e da tricocefalíase por meio de dose única de mebendazole. Rev. Bras. Clínic. Terap. 5:269-272, 1976.

[2] 2. BANZON, T.C., SINGSON, C.N. and CROSS, J.H. Mebendazole treatment for intestinal nematodes in a Philippine barrio. J. Philipp Med. Ass. 52: 239-243, 1976. In Trop. Dis. Bull. 74:246, 1977.

[3] 3. BRUGMANS, J.P., THIENPONT, C.D., VAN WINJNGAARDEN, I., VANPARYS, O.F., SCHUERMANS, V.L. e LAURVERS, H.L. Mebendazole in anterobiais. Radiochemical and pilot clinicai study in 1278 subjects. Jour. Am. Med. Ass. 217:313-316, 1971.

[4] 4. CAMPOS, R., CIMERMAN, B" CASTANHO, R.P., TORRE, M.C.C.D. e CASTILHO, V.L.P. Tratamento de helmintíases intestinais com a associação mebendazol e tiabendazol. Rev. Bras. Clin. Terap. 5: 23-26, 1976.

[5] 5. CHAIA, G. e CUNHA, A.S. Terapeutic action of mebendazole (R.17.635) against human helminthiasis. Folha med. 63:843-852, 1971.

[6] 6. CHAVARRIA, A.P., SWARTZWELDER, J.C., VILLAREJOS, V.M. e ZELEDÓN, R. Mebendazole, an effective broadspectrum anthelmintic. Am. Jour. Trop. Med. Hyg. 22: 592-595, 1973.

[7] 7. COPELMAN, H. 0 mebendazole no tratamento da teníase. XXV Cong. Bras. Gastroenterologia.

[8] 8. DAVIS, A. Drug treatment in intestinal helminthiases. World Health Org. 1973.

[9] 9. GRAHAN, C.F. A device for the diagnosis of Enterobius infection. Am. Jour. Trop. Med. 21:159-161, 1941.

[10] 10. KATZ, N" CHAVES, A. e PELLEGRINO, J. A simple device for quantitative stool thick - smear technique in schistosomiasis mansoni. Rev. Inst. Med. Trop. São Paulo. 14: 397-400, 1972.

[11] 11. KATZ, N. e ZICKER, F. Ensaio clínico com mebendazole nas teníases. Rev. Soc. Med. Trop. 7:225-229, 1973.

[12] 12. MORAIS, R.G. Contribuição para o estudo do Strongyloides stercoralis e da estrongiloidose no Brasil. Rev. Serviço Esp. Saúde Públ. 1: 507, 1948.

[13] 13. SHIRATSUCHI, M.S., LEVI, G.C., AMATO NETO, V., AVI LA, C.A., STEFANl, H.N.V., MOSTERIO, L" TSUKUMO, M.K.K., KONICHI, S.R. e CORREA, L.L. Tratamento da tricococefaliase pelo mebendazole. Resultados obtidos. Rev. Inst. Med. Trop. São Paulo. 17:206-209, 1975.

[14] 14. SOUZA, D.W.C., SOUZA, M.S.L. e NEVES, J. Ação terapêutica do mebendazole (R.17.635) em pacientes poliparasitados. Resultados preliminares. Rev. Inst. Med. Trop. São Paulo. 15: 30-33, 1973.

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Associação do tiabendazol com mebendazol no tratamento das helmintoses intestinais

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