Descriptive analysis of syphilis cases reported in Mato Grosso do Sul, Brazil identifies failure in treatment

This study analyzed syphilis cases listed in the Information System on Diseases of Compulsory Declaration (SINAN) of Mato Grosso do Sul state in Brazil between January 2013 and December 2014.

RESULTS:

Most of the evaluated syphilis cases would have been preventable through public education, particularly congenital syphilis in children of previously diagnosed mothers and infection by untreated sexual partners.

CONCLUSIONS:

The incidence rate of syphilis could be reduced by improving prevention through counselling on the risk of infection, improving access to condoms, and increasing the frequency of diagnostic tests.

Keywords:
Treponema pallidum; SINAN; Mato Grosso do Sul; Descriptive analysis; Syphilis

Variables	Cases	%
Number of syphilis	2,207
Gender
Male	1,311	59
Female	895	40
Undefined	1	0.05
Race
White	574	26
Black	98	4
Asian	19	1
Mixed	851	39
Indigenous	34	1
Data missing	631	29
Age
≤19	214	9
20-29	688	31
30-39	481	22
≥40	806	36
Data missing	18	0.8
Schooling
Illiterate	23	1
Primary	990	45
Secondary	88	4
Data missing	1,106	50

Variables	Cases	%
Total cases	1,497
Race
White	470	31
Black	78	5
Asian	12	1
Mixed	775	51
Indigenous	101	6
Data missing	81	5
Age
≤19	401	26
20-29	733	48
30-39	345	22
≥40	37	2
Data missing	1	0.06
Schooling
Illiterate	17	1
Primary	1,083	71
Secondary	23	1
Data missing	394	26
Treponemic test reagent
Reagent	1,115	73
Unrealized	236	15
Data missing	166	12
Non-treponemic test
Reagent	1,163	77
Non-reagent	106	7
Not performed	172	11
Data missing	76	5
Clinical classification
Primary	518	34
Secondary	68	5
Tertiary	316	21
Latent	158	10
Data missing	457	30
Treatment
Penicillin G 2.400.000UI	289	19
Penicillin G 4.800.000UI	28	1
Penicillin G 7.200.000UI	1,054	70
Another antibiotic	20	1
Not treated	72	5
Data missing	54	4
Sexual partner treatment
Treated	756	50
Not treated	528	35
Data missing	233	15

Variables	Cases	%
Number	417
Gender
Male	218	52
Female	190	45
Undefined	9	2
Race	Son/Mother
White	154/101	37/24
Black	7/17	1/4
Asian	1/0	0.2/0
Mixed	195/260	47/62
Indigenous	21/28	5/7
Data missing	39/11	9/2
Diagnosis of maternal syphilis	245	58
Treponemal confirmatory test at birth	156	37
Non-treponemal test at birth	328	77
Non-treponemal test	Blood/Liquor
Reagent	295/8	71/1.9
Non-reagent	62/110	15/26
Not performed	39/231	9/55
Data missing	21/68	5/16
Clinical manifestations
Changes in long bones (radiological tests)	11	2.6
Osteochondritis	5	1.2
Cutaneous lesions	9	2.1
Jaundice	40	9
Anemia	15	3
Splenomegaly	5	1.2
Hepatomegaly	8	1.9
Pseudoparalysis	2	0.48
Case evolution
Alive	355	85
Death by syphilis	4	0.96
Death by another cause	6	1.4
Abortion	4	0.96
Stillborn	13	3
Data missing	35	8

Sociedade Brasileira de Medicina Tropical - SBMT Caixa Postal 118, 38001-970 Uberaba MG Brazil, Tel.: +55 34 3318-5255 / +55 34 3318-5636/ +55 34 3318-5287, http://rsbmt.org.br/ - Uberaba - MG - Brazil
E-mail: rsbmt@uftm.edu.br

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[1] Corresponding author: Simone Simionatto. E-mail:simonesimionatto@ufgd.edu.br