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Short Communication • Rev. Soc. Bras. Med. Trop. 52 • 2019 • https://doi.org/10.1590/0037-8682-0502-2018   copy

Origanum vulgare L. essential oil inhibits the growth of carbapenem-resistant gram-negative bacteria

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

INTRODUCTION:

Plant products are sources for drug development against multidrug resistant bacteria.

METHODS

The antimicrobial activity of Origanum vulgare L. essential oil (OVeo) against carbapenem-resistant strains was assessed by disk-diffusion, microdilution (REMA-Resazurin Microtiter Assay), and time kill assays.

RESULTS

Carbapenemase production was confirmed for all strains. OVeo exhibited a minimum inhibitory concentration of 0.059% v/v for Klebsiella pneumoniae and Serratia marcescens, and of 0.015 % v/v for Acinetobacter baumannii. A decrease in cell count was observed after a 4 h treatment.

CONCLUSIONS

OVeo antimicrobial effect was rapid and consistent, making it a candidate for developing alternative therapeutic options against carbapenem-resistant strains.

Keywords:
Oregano; Carbapenemase; Multidrug resistance; Antimicrobial activity

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