The authors followed-up 50 patients with ascariasis treated with Piperazine Hydrate 20% using the single dose of 0.5 ml/Kg of body weight. The dosage was not exceeding 6.0 gm. Consequently, they had a radical cure in 76% of the cases and in 98% a reduction in the elimination of eggs in the stool. The tolerance to the produtc was excellent, only two patients refered to mild side-effects consisting of nausea, vommiting, and dizziness.