A follow-up case report on Chagas' disease is presented, from the initial infection through the demise, five years later. In the early stage of the disease, there was radiologic and electrocar- diographic evidence of cardiac involvement, with spontaneous regression up to the siíteenth month. Aperstalsis of the esophagus developed within 4 months after the initial infectiorc, and megacolon 4 1/2 years later. The patient died in the postoperative period, following surgery for rectosigmoidectomy. At autopsy there was dilatation of the esophague and sigmoid colon; the muscle layer of the esophagus, small bowel, sigmoid colon and heart showed inflammatory changes and the number of neurons in the esophageal muscle layer was greatly reduced. Nets of leishmania could not be found