Trends in primary multidrug-resistant tuberculosis in the State of Rio de Janeiro: a retrospective study conducted during 2000-2019

We performed a time series analysis of primary MDR-TB cases reported in the State of Rio de Janeiro (RJ) during 2000-2019. The annual percent change and the average annual percentage change (AAPC) were computed using joinpoint regression analysis.

RESULTS:

The percentage of cases increased from 7.69% in 2000 to 38.42% in 2018. We observed an upward trend during this period (AAPC = 9.4; 95% confidence interval 1.4-18.0, p < 0.001).

CONCLUSIONS:

The trend indicates the increasing occurrence of MDR-TB transmission sources in RJ during 2000-2019.

Keywords:
Tuberculosis; Epidemiological monitoring; Drug resistance; Time-series studies

Year	Total cases of MDR-TB notified	Primary resistance	Acquired resistance	% Primary MDR-TB
2000	117	9	108	7.69
2001	122	12	110	9.84
2002	139	18	121	12.95
2003	113	10	103	8.85
2004	109	11	98	10.09
2005	104	12	92	11.54
2006	102	12	90	11.76
2007	98	19	79	19.39
2008	106	20	86	18.87
2009	102	22	80	21.57
2010	144	28	116	19.44
2011	150	28	122	18.67
2012	193	25	168	12.95
2013	173	16	157	9.25
2014	185	19	166	10.27
2015	154	37	117	24.03
2016	157	49	109	31.21
2017	181	57	124	31.49
2018	177	68	109	38.42
2019	164	61	103	37.2

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[1] Corresponding author: Marcela Bhering. e-mail:marbhering@gmail.com