Introduction
Mixed-species biofilms are involved in a wide variety of infections. We studied the synergistic interactions during dual-species biofilm formation among isolates of Pseudomonas aeruginosa, Acinetobacter baumannii, and Stenotrophomonas maltophilia.
Methods
Isolates were cultured as single-species and all possible combinations of dual-species biofilms.
Results
The 61 A. baumannii biofilms increased by 26-fold when cultured with S. maltophilia isolates; 62 A. baumannii biofilms increased by 20-fold when cultured with S. maltophilia isolates; and 31 P. aeruginosa biofilms increased by 102-fold when cultured with S. maltophilia 106.
Conclusions
Synergy was observed between two isolates, including those that inherently lacked biofilm formation ability.
Chronic infection; Mixed-species biofilm; Synergy
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