Association of adverse drug reaction to anti-tuberculosis medication with quality of life in patients in a tertiary referral hospital

Valadares, Ronise Malaquias Carlos; Carvalho, Wânia da Silva; Miranda, Silvana Spíndola de

doi:10.1590/0037-8682-0207-2019

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Short Communication • Rev. Soc. Bras. Med. Trop. 53 • 2020 • https://doi.org/10.1590/0037-8682-0207-2019 copy

Association of adverse drug reaction to anti-tuberculosis medication with quality of life in patients in a tertiary referral hospital

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

INTRODUCTION:

Adverse drug reactions can develop when using anti-tuberculosis medication, and the effects of the drugs can also significantly hinder the treatment of patients.

METHODS:

A cross-sectional survey was conducted in 73 patients using two standardized questionnaires and the World Health Organization Quality of Life-Bref.

RESULTS:

All patients reported the presence of adverse drug reactions, 71.6% of which are minor and 28.3% both major and minor. The global quality of life analysis showed that patients with tuberculosis have a good average (67.3%).

CONCLUSIONS:

There is an association between quality of life and adverse drug reaction, educational level, and vulnerability.

Keywords:
Tuberculosis; Anti-tuberculosis agents; Adverse reactions; Quality of life

Adverse drug reactions		Patients with ADR
		n	%
Gastrointestinal	Increased appetite	36	49.3
	Nausea	28	38.3
	Anorexia	21	28.8
	Diarrhea	20	27.4
	Epigastralgia	18	24.7
	Constipation	15	20.5
	Heartburn	12	16.4
	Hepatitis	2	2.7
Dermatological	Pruritus	24	32.9
	Exfoliative dermatitis	16	21.9
	Rash	9	12.3
	Acneiform spots	2	2.7
Osteoarticular	Arthralgia	21	28.8
Osteoarticular	Arthritis	6	8.2
Psychiatric	Emotionalism	34	46.6
	Anxiety	30	41.1
	Alterations in memory and concentration	18	24.6
	Psychosis	12	16.4
	Aggression	9	12.3
	Euphoria	5	6.8
Neurological	Dry mouth	41	56.2
	Postural hypotension	34	46.6
	Insomnia	27	37.0
	Drowsiness	18	24.6
	Vestibulocochlear toxicity	3	4.1
Hematological	Anemia	8	11.0
Renal	Dysuria	41	56.2
	Difficulty in urination	5	6.8
Other effects	Red urine	50	68.5
	Red feces	26	35.6
	Alteration in the visual field	26	35.6
	Fever	10	13.7
	Flu	3	4.1
	Oligo- or amenorrhea	3	4.1
	Alteration in color vision	1	1.4
	Asthma	1	1.4

Area	Average	%	Pattern deviation	Global coefficient	P-value
Global	13.5	67.3	1.50	1.0
Physical	12.2	61.2	1.96	0.664	<0.001
Psychological	14.5	72.7	2.22	0.803	<0,001
Social relations	11.3	56.4	2.92	0.390	<0.001
Environmental	14.3	71.3	1.82	0.642	<0.001

Variable	Univariate		Multivariate
Variable	P-value	Confidence Interval (95%)	Coefficient	P-value
Sex	0.643	(-0.990-0.0615)
Female
Male
Educational level
Illiterate
Primary	0.022	(0.276-3.388)	0.848	0.047
Secondary	0.060	(-0.070-3.419)
Higher	0.013	(0.580-4.805)	2.185	0.008
Unknown
Age, years	0.076	(-1.398-0.071)
18-40
>40
Race/ethnicity
White
Black	0.806	(-1.056-1.354)
Olive-skinned	0.540	(-0.766-1.452)
Special population
Prisoner
Homeless population	0.109	(-3.600-0.370)
No	0.623	(-2.163-1.304)	-1.634	0.006
Input type
New case
Relapse	0.794	(-0.805-1.048)
Re-admitted after cessation	0.645	(-1.019-0.635)
Length of exposure	0.696	-(0.004-0.005)
Associated disorders
Alcoholism	0.939	(-0.679-0.733)
Smoking	0.864	(-0.767-0645)
Sensibility profile	0.092	(-0.108-1.399)
Sensitive
Resistant
Type of ADR	0.016	(-1.793-0.192)	-1.040	0.012

Sociedade Brasileira de Medicina Tropical - SBMT Caixa Postal 118, 38001-970 Uberaba MG Brazil, Tel.: +55 34 3318-5255 / +55 34 3318-5636/ +55 34 3318-5287, http://rsbmt.org.br/ - Uberaba - MG - Brazil
E-mail: rsbmt@uftm.edu.br

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[1] Corresponding author: Silvana Spíndola de Miranda. e-mail: silvanaspindola@gmail.com