A1 |
Malle et al. (2021)1919. Malle L, Gao C, Hur C, et al. Individuals with Down syndrome hospitalized with COVID-19 have more severe disease. Genet Med. 2021;23(3):576-80. PMID: 33060835; https://doi.org/10.1038/s41436-020-01004-w. https://doi.org/10.1038/s41436-020-01004...
|
USA |
Case-control |
IV |
12 |
A2 |
El Kaouini et al. (2021)3030. El Kaouini A, El Rhalete A, Aabdi M, et al. COVID 19 pneumonia in Down syndrome patients: About 2 cases. Ann Med Surg. 2021;65:102324. PMID: 33907623; https://doi.org/10.1016/j.amsu.2021.102324. https://doi.org/10.1016/j.amsu.2021.1023...
|
Morocco |
Case report |
VI |
2 |
A3 |
De Cauwer and Spaepen (2021)6565. De Cauwer H, Spaepen A. Are patients with Down syndrome vulnerable to life-threatening COVID-19? Acta Neurol Belg. 2021;121(3):685-7. PMID: 32444942; https://doi.org/10.1007/s13760-020-01373-8. https://doi.org/10.1007/s13760-020-01373...
|
Belgium |
Case series |
VI |
4 |
A4 |
Dard, Janel and Vialard (2020)7070. Dard R, Janel N, Vialard F. COVID-19 and Down’s syndrome: are we heading for a disaster? Eur J Hum Genet. 2020;28(11):1477-8. PMID: 32686759; https://doi.org/10.1038/s41431-020-0696-7. https://doi.org/10.1038/s41431-020-0696-...
|
France |
Expert opinion |
VII |
0 |
A5 |
Wadman (2020)7171. Wadman M. People with Down syndrome face high risk from coronavirus. Science. 2020;370(6523):1384-5. PMID: 33335039; https://doi.org/10.1126/science.370.6523.1384. https://doi.org/10.1126/science.370.6523...
|
USA |
Expert opinion |
VII |
1 |
A6 |
Del Carmen et al. (2020)7575. Del Carmen Ortega M, Borrel JM, de Jesús Bermejo T, et al. Lessons from individuals with Down syndrome during COVID-19. Lancet Neurol. 2020;19(12):974-5. PMID: 33212059; https://doi.org/10.1016/s1474-4422(20)30401-4. https://doi.org/10.1016/s1474-4422(20)30...
|
Spain |
Expert opinion |
VII |
0 |
A7 |
Kantar et al. (2020)3636. Kantar A, Mazza A, Bonanomi E, et al. COVID-19 and children with Down syndrome: is there any real reason to worry? Two case reports with severe course. BMC Pediatr. 2020;20(1):561. PMID: 33339516; https://doi.org/10.1186/s12887-020-02471-5. https://doi.org/10.1186/s12887-020-02471...
|
Italy |
Case report |
VI |
2 |
A8 |
Real de Asua et al. (2021)3737. Real de Asua D, Mayer MA, Ortega MC, et al. Comparison of COVID-19 and non-COVID-19 pneumonia in Down syndrome. J Clin Med. 2021;10(16):3748. PMID: 34442043; https://doi.org/10.3390/jcm10163748. https://doi.org/10.3390/jcm10163748...
|
Spain |
Cohort |
IV |
86 |
A9 |
Russo et al. (2020)7474. Russo GC, Bernardes N, Baraldi NR, et al. Ações contra a Covid-19 na população com síndrome de Down. Arq Bras Cardiol. 2020;115(5):939-41. PMID: 33295460; https://doi.org/10.36660/abc.20200685. https://doi.org/10.36660/abc.20200685...
|
Brazil |
Expert opinion |
VII |
0 |
A10 |
Babamahmoodi et al. (2020)6666. Babamahmoodi A, Moniri A, Sadr M, et al. Trisomy 21 as a risk factor for severe illness in COVID-19: Report of two Cases. Tanaffos. 2020;19(4):413-7. PMID: 33959180. |
Iran |
Case report |
VI |
2 |
A11 |
Villani et al. (2020)3838. Villani ER, Carfì A, Di Paola A, et al. Clinical characteristics of individuals with Down syndrome deceased with CoVID-19 in Italy-A case series. Am J Med Genet. 2020;182(12):2964-70. PMID: 32918520; https://doi.org/10.1002/ajmg.a.61867. https://doi.org/10.1002/ajmg.a.61867...
|
Italy |
Case series |
VI |
16 |
A12 |
Robayo et al. (2021)3939. Robayo-Amortegui H, Valenzuela-Faccini N, Quecano-Rosas C, Zabala-Muñoz D, Perez-Garzon M. Cerebral venous thrombosis in a patient with Down syndrome and coronavirus disease 2019: a case report. J Med Case Rep. 2021;15(1):364. PMID: 34253238; https://doi.org/10.1186/s13256-021-02908-0. https://doi.org/10.1186/s13256-021-02908...
|
Colombia |
Case report |
VI |
1 |
A13 |
Khoshnood et al. (2021)4040. Khoshnood M, Mahabir R, Shillingford NM, Santoro JD. Post-infectious inflammatory syndrome associated with SARS-CoV-2 in a paediatric patient with Down syndrome. BMJ Case Rep. 2021;14(4):e240490. PMID: 33858888; https://doi.org/10.1136/bcr-2020-240490. https://doi.org/10.1136/bcr-2020-240490...
|
USA |
Case report |
VI |
1 |
A14 |
Vita et al. (2021)77. Vita S, Di Bari V, Corpolongo A, et al. Down syndrome patients with COVID-19 pneumonia: a high-risk category for unfavourable outcome. Int J Infect Dis. 2021;103:607-10. PMID: 33271290; http://doi.org/10.1016/j.ijid.2020.11.188. https://doi.org/10.1016/j.ijid.2020.11.1...
|
Italy |
Case report |
VI |
2 |
A15 |
Altable and de la Serna (2021)6767. Altable M, de la Serna JM. Down’s syndrome and COVID-19: risk or protection factor against infection? A molecular and genetic approach. Neurol Sci. 2021;42(2):407-13. PMID: 33231770; https://doi.org/10.1007/s10072-020-04880-x. https://doi.org/10.1007/s10072-020-04880...
|
Spain |
Narrative review |
VII |
0 |
A16 |
Kim-Hellmuth et al. (2021)4141. Kim-Hellmuth S, Hermann M, Eilenberger J, et al. SARS-CoV-2 triggering severe acute respiratory distress syndrome and secondary hemophagocytic lymphohistiocytosis in a 3-year-old child with Down syndrome. J Pediatr Infect Dis Soc. 2021;10(4):543-6. PMID: 33188394; https://doi.org/10.1093/jpids/piaa148. https://doi.org/10.1093/jpids/piaa148...
|
Germany |
Case report |
VI |
1 |
A17 |
Krishnan et al. (2020)4242. Krishnan US, Krishnan SS, Jain S, et al. SARS-CoV-2 infection in patients with Down syndrome, congenital heart disease, and pulmonary hypertension: is down syndrome a risk factor? J Pediatr. 2020;225:246-8. PMID: 32610168; https://doi.org/10.1016/j.jpeds.2020.06.076. https://doi.org/10.1016/j.jpeds.2020.06....
|
USA |
Case series |
VI |
3 |
A18 |
Emami et al. (2021)2020. Emami A, Javanmardi F, Akbari A, Asadi-Pooya AA. COVID-19 in patients with Down syndrome. Neurol Sci. 2021;42(5):1649–52. PMID: 33523318; https://doi.org/10.1007/s10072-021-05091-8. https://doi.org/10.1007/s10072-021-05091...
|
Iran |
Case-control |
IV |
18 |
A19 |
Clift et al. (2021)2121. Clift AK, Coupland CAC, Keogh RH, Hemingway H, Hippisley-Cox J. COVID-19 mortality risk in down syndrome: results from a cohort study of 8 million adults. Ann Intern Med. 2021;174(4):572-6. PMID: 33085509; https://doi.org/10.7326/m20-4986. https://doi.org/10.7326/m20-4986...
|
UK |
Cohort |
IV |
4,053 |
A20 |
Newman et al. (2021)2222. Newman AM, Jhaveri R, Patel AB, et al. Trisomy 21 and coronavirus disease 2019 in pediatric patients. J Pediatr. 2021;228:294-6. PMID: 32861693; https://doi.org/10.1016/j.jpeds.2020.08.067. https://doi.org/10.1016/j.jpeds.2020.08....
|
USA |
Case series |
VI |
4 |
A21 |
Stefanuto et al. (2021)2323. Stefanuto PPG, Fernandes CJS, da Cruz CG, Leite RD, Tavares LVS. COVID-19 em criança com síndrome de down e tuberculose pulmonar extensa: relato de caso. Rev Bras Saúde Matern Infant. 2021;21(suppl 2):s559-s563. https://doi.org/10.1590/1806-9304202100S200013. https://doi.org/10.1590/1806-9304202100S...
|
Brazil |
Case report |
VI |
1 |
A22 |
Simpson et al. (2020)2424. Simpson M, Collins C, Nash DB, Panesar LE, Oster ME. Coronavirus disease 2019 infection in children with pre-existing heart disease. J Pediatr. 2020;227:302-7. PMID: 32730815; https://doi.org/10.1016/j.jpeds.2020.07.069. https://doi.org/10.1016/j.jpeds.2020.07....
|
Georgia |
Case series |
VI |
3 |
A23 |
Perera et al. (2020)2525. Perera B, Laugharne R, Henley W, et al. COVID-19 deaths in people with intellectual disability in the UK and Ireland: descriptive study. BJPsych open. 2020;6(6):e123. PMID: 33059790; https://doi.org/10.1192/bjo.2020.102. https://doi.org/10.1192/bjo.2020.102...
|
England and Ireland |
Case series |
VI |
20 |
A24 |
Oyanagi et al. (2021)2626. Oyanagi T, Tomita K, Furuichi M, Shinjoh M, Yamagishi H. Successful resuscitation from SARS-CoV-2 infection in a child after Rastelli operation. Pediatr Int. 2021;63(6):730-2. PMID: 34089270; https://doi.org/10.1111/ped.14479. https://doi.org/10.1111/ped.14479...
|
Japan |
Case report |
VI |
1 |
A25 |
Malle et al. (2021)2727. Malle L, Bastard P, Martin-Nalda A, et al. Atypical inflammatory syndrome triggered by SARS-CoV-2 in infants with Down syndrome. J Clin Immunol. 2021;41(7):1457-62. PMID: 34089457; https://doi.org/10.1007/s10875-021-01078-4. https://doi.org/10.1007/s10875-021-01078...
|
USA and Spain |
Case report |
VI |
2 |
A26 |
Huls et al. (2021)2828. Hüls A, Costa ACS, Dierssen M, et al. Medical vulnerability of individuals with Down syndrome to severe COVID-19–data from the Trisomy 21 Research Society and the UK ISARIC4C survey. eClinicalMedicine. 2021;33:100769. PMID: 33644721; https://doi.org/10.1016/j.eclinm.2021.100769. https://doi.org/10.1016/j.eclinm.2021.10...
|
USA, UK, Brazil, Italy, Spain, France, India |
Case-control |
IV |
1,046 |
A27 |
Alsahabi et al. (2021)2929. Alsahabi I, Alobaidi A, Alahmari AS, Almohsen N, Alhamoud AH. Clinical presentation and successful management of an infant with Down syndrome and COVID-19 in Riyadh, Saudi Arabia. Cureus. 2021;13(2):e13188. PMID: 33575158; https://doi.org/10.7759/cureus.13188. https://doi.org/10.7759/cureus.13188...
|
Saudi Arabia |
Case report |
VI |
1 |
A28 |
Landes et al. (2021)7272. Landes SD, Turk MA, Damiani MR, Proctor P, Baier S. Risk factors associated with COVID-19 outcomes among people with intellectual and developmental disabilities receiving residential services. JAMA Netw Open. 2021;4(6):e2112862. PMID: 34100935; https://doi.org/10.1001/jamanetworkopen.2021.12862. https://doi.org/10.1001/jamanetworkopen....
|
USA |
Cohort |
IV |
20 |
A29 |
De Toma and Dierssen (2021)5353. De Toma I, Dierssen M. Network analysis of Down syndrome and SARS-CoV-2 identifies risk and protective factors for COVID-19. Sci Rep. 2021;11(1):1930. PMID: 33479353; https://doi.org/10.1038/s41598-021-81451-w. https://doi.org/10.1038/s41598-021-81451...
|
Spain |
Narrative review |
VII |
0 |
A30 |
Hippisley-Cox et al. (2021)6363. Hippisley-Cox J, Coupland CA, Mehta N, et al. Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: national prospective cohort study. BMJ. 2021;374:n2244. PMID: 34535466; https://doi.org/10.1136/bmj.n2244. https://doi.org/10.1136/bmj.n2244...
|
England |
Cohort |
IV |
3,963* |
A31 |
Williamson et al. (2021)5555. Williamson EJ, McDonald HI, Bhaskaran K, et al. Risks of covid-19 hospital admission and death for people with learning disability: Population based cohort study using the OpenSAFELY platform. BMJ. 2021;374:n1592. PMID: 34261639; https://doi.org/10.1136/bmj.n1592. https://doi.org/10.1136/bmj.n1592...
|
England |
Cohort |
IV |
341 |
A32 |
Semenzato et al. (2021)5656. Semenzato L, Botton J, Drouin J, et al. Chronic diseases, health conditions and risk of COVID-19-related hospitalization and in-hospital mortality during the first wave of the epidemic in France: a cohort study of 66 million people. Lancet Reg Heal Eur. 2021;8:100158. PMID: 34308411; https://doi.org/10.1016/j.lanepe.2021.100158. https://doi.org/10.1016/j.lanepe.2021.10...
|
France |
Cohort |
IV |
256 |
A33 |
Santos et al. (2020)6464. Santos MM, Lucena EES, Lima KC, et al. Survival and predictors of deaths of patients hospitalised due to COVID-19 from a retrospective and multicentre cohort study in Brazil. Epidemiol Infect. 2020;148:e198. PMID: 32892789; https://doi.org/10.1017/s0950268820002034. https://doi.org/10.1017/s095026882000203...
|
Brazil |
Cohort |
IV |
73 |
A34 |
Bergman et al. (2021)5757. Bergman J, Ballin M, Nordström A, Nordström P. Risk factors for COVID-19 diagnosis, hospitalization, and subsequent all-cause mortality in Sweden: a nationwide study. Eur J Epidemiol. 2021;36(3):287-98. PMID: 33704634; https://doi.org/10.1007/s10654-021-00732-w. https://doi.org/10.1007/s10654-021-00732...
|
Sweden |
Case-control |
IV |
85 |
A35 |
Illouz et al. (2021)3131. Illouz T, Biragyn A, Frenkel-Morgenstern M, et al. Specific susceptibility to COVID-19 in adults with Down syndrome. Neuromolecular Med. 2021;23(4):561-71. PMID: 33660221; https://doi.org/10.1007/s12017-021-08651-5. https://doi.org/10.1007/s12017-021-08651...
|
Israel |
Cohort |
IV and VI |
20 |
A36 |
Illouz et al. (2021)6868. Illouz T, Biragyn A, Iulita MF, et al. Immune dysregulation and the increased risk of complications and mortality following respiratory tract infections in adults with Down syndrome. Front Immunol. 2021;12:621440. PMID: 34248930; https://doi.org/10.3389/fimmu.2021.621440. https://doi.org/10.3389/fimmu.2021.62144...
|
Israel, USA, Spain, Canada, Switzerland. |
Narrative review |
VII |
0 |
A37 |
Espinosa (2020)5151. Espinosa JM. Down Syndrome and COVID-19: A Perfect Storm? Cell Reports Med. 2020;1(2):100019. PMID: 32501455; https://doi.org/10.1016/j.xcrm.2020.100019. https://doi.org/10.1016/j.xcrm.2020.1000...
|
USA |
Narrative review |
VII |
0 |
A38 |
Ma et al. (2021)4949. Ma Y, Deutsch G, Van Tassel D, et al. SARS-CoV-2 Related ischemic colitis in an adolescent with trisomy 21: diagnostic pitfalls and considerations. Pediatr Dev Pathol. 2021;24(5):445-9. PMID: 34048305; https://doi.org/10.1177/10935266211015666. https://doi.org/10.1177/1093526621101566...
|
USA |
Case report |
VI |
1 |
A39 |
Amin et al. (2022)3232. Amin MA, Khan II, Nahin S, et al. COVID-19 hospitalization with later long COVID in a person with Down syndrome. Clin Case Rep. 2022;10(10):e6425. PMID: 36245462; https://doi.org/10.1002/ccr3.6425. https://doi.org/10.1002/ccr3.6425...
|
Bangladesh |
Case report |
VI |
1 |
A40 |
Baksh et al. (2022)3333. Baksh RA, Strydom A, Pape SE, Chan LF, Gulliford MC. Susceptibility to COVID-19 diagnosis in people with Down syndrome compared to the general population: matched-cohort study using primary care electronic records in the UK. J Gen Intern Med. 2022;37(8):2009-15. PMID: 35386043; https://doi.org/10.1007/s11606-022-07420-9. https://doi.org/10.1007/s11606-022-07420...
|
UK |
Cohort |
IV |
651 |
A41 |
Boschiero (2022)5858. Boschiero MN, Lutti Filho JR, Ortega MM, Marson FAL. High case fatality rate in individuals with Down syndrome and COVID-19 in Brazil: a two-year report. J Clin Pathol. 2022;75(10):717-20. PMID: 35764375; https://doi.org/10.1136/jcp-2021-207802. https://doi.org/10.1136/jcp-2021-207802...
|
Brazil |
Cohort |
IV |
5,152 |
A42 |
Emes et al. (2021)4646. Emes D, Hüls A, Baumer N, et al. Covid-19 in children with Down syndrome: Data from the Trisomy 21 Research Society Survey. J Clin Med. 2021;10(21):5125. PMID: 34768645; https://doi.org/10.3390/jcm10215125. https://doi.org/10.3390/jcm10215125...
|
USA, UK, Brazil, Italy, Spain, France, India, Germany |
Cohort |
IV |
328 |
A43 |
Evangelho et al. (2022)5454. Evangelho VGO, Bello ML, Castro HC, Amorim MR. Down syndrome: the aggravation of COVID-19 may be partially justified by the expression of TMPRSS2. Neurol Sci. 2022;43(2):789-90. PMID: 34757552; https://doi.org/10.1007/s10072-021-05715-z. https://doi.org/10.1007/s10072-021-05715...
|
Brazil |
Expert opinion |
VII |
0 |
A44 |
Kobayashi et al. (2022)4343. Kobayashi H, Akiniwa M, Yamaguchi Y, Hirai Y, Aoki A. COVID-19 in an adult with Down syndrome: impact on autoimmune response. Case Rep Infect Dis. 2022;2022:6128496. PMID: 35433064; https://doi.org/10.1155/2022/6128496. https://doi.org/10.1155/2022/6128496...
|
Japan |
Case report |
VI |
1 |
A45 |
Koyama et al. (2022)6262. Koyama A, Koumans EH, Sircar K, et al. Severe outcomes, readmission, and length of stay among COVID-19 patients with intellectual and developmental disabilities. Int J Infect Dis. 2022;116:328-30. PMID: 35077878; https://doi.org/10.1016/j.ijid.2022.01.038. https://doi.org/10.1016/j.ijid.2022.01.0...
|
USA |
Cohort |
IV |
1,412 |
A46 |
Ku et al. (2022)5959. Ku JH, Levin MJ, Luo Y, et al. Risk of severe coronavirus disease 2019 disease in individuals with Down syndrome: a matched cohort study from a large, integrated health care system. J Infect Dis. 2022;226(5):757-65. PMID: 35749312; https://doi.org/10.1093/infdis/jiac236. https://doi.org/10.1093/infdis/jiac236...
|
USA |
Cohort |
IV |
142 |
A47 |
Kuczborska, Buda and Ksiazyk (2022)4444. Kuczborska K, Buda P, Książyk JB. Different course of SARS-CoV-2 infection in two adolescents with other immunosuppressive factors. Cureus. 2022;14(2):e22710. PMID: 35386177; https://doi.org/10.7759/cureus.22710. https://doi.org/10.7759/cureus.22710...
|
Poland |
Case Report |
VI |
1 |
A48 |
Pinku et al. (2022)3434. Pinku H, Hüls A, Feany PT, et al. Differences in clinical presentation, severity, and treatment of COVID-19 among individuals with Down syndrome from India and high-income countries: Data from the Trisomy 21 Research Society survey. J Glob Health. 2022;12:05035. PMID: 35932238; https://doi.org/10.7189/jogh.12.05035. https://doi.org/10.7189/jogh.12.05035...
|
UK, India |
Cohort |
IV |
1,272 |
A49 |
Shi et al. (2022)6060. Shi T, Pan J, Moore E, et al. Risk of COVID-19 hospitalizations among school-aged children in Scotland: A national incident cohort study. J Glob Health. 2022;12:05044. PMID: 36134546; https://doi.org/10.7189/jogh.12.05044. https://doi.org/10.7189/jogh.12.05044...
|
Scotland |
Cohort |
IV |
79 |
A50 |
Silva et al. (2022)3535. Silva DL, Lima CM, Magalhães VCR, et al. Down syndrome and COVID-19, a combination with a poor prognosis. Int J Tuberc Lung Dis. 2022;26(1):77-9. PMID: 34969435; https://doi.org/10.5588/ijtld.21.0605. https://doi.org/10.5588/ijtld.21.0605...
|
Brazil |
Case series |
VI |
3 |
A51 |
Lunsky et al. (2022)6161. Lunsky Y, Durbin A, Balogh R, et al. COVID-19 positivity rates, hospitalizations and mortality of adults with and without intellectual and developmental disabilities in Ontario, Canada. Disabil Health J. 2022;15(1):101174. PMID: 34340949; https://doi.org/10.1016/j.dhjo.2021.101174. https://doi.org/10.1016/j.dhjo.2021.1011...
|
Canada |
Cohort |
IV |
121 |
A52 |
Majithia and Ribeiro (2022)5050. Majithia M, Ribeiro SP. COVID-19 and Down syndrome: the spark in the fuel. Nat Rev Immunol. 2022;22(7):404-5. PMID: 35672483; https://doi.org/10.1038/s41577-022-00745-w. https://doi.org/10.1038/s41577-022-00745...
|
USA |
Expert opinion |
VII |
0 |
A53 |
Magalhães et al. (2022)4545. Magalhães BK, Queiroz F, Salomão MLM, de Godoy MF. The impact of chronic cardiovascular disease on COVID-19 clinical course. J Clin Transl Res. 2022;8(4):308-22. PMID: 35991082. |
Brazil |
Case-control |
IV |
7 |
A54 |
Parasini et al. (2022)5252. Parisini A, Boni S, Vacca EB, et al. Down syndrome and COVID-19: not always a poor prognosis. Int J Tuberc Lung Dis. 2022;26(7):691-3. PMID: 35768929; https://doi.org/10.5588/ijtld.22.0192. https://doi.org/10.5588/ijtld.22.0192...
|
Italy |
Case series |
VI |
6 |
A55 |
Atkinson et al. (2022)6969. Atkinson TP. Defective immune response to SARS-CoV-2 immunization in Down syndrome correlates with increased susceptibility to severe illness with infection. J Infect Dis. 2022;226(5):755-6. PMID: 35749348; https://doi.org/10.1093/infdis/jiac237. https://doi.org/10.1093/infdis/jiac237...
|
USA |
Expert opinion |
VII |
0 |