ABSTRACT
BACKGROUND:
Coronavirus disease 2019 (COVID-19) is an ongoing global health threat. However, currently, no standard therapy has been approved for the disease.
OBJECTIVES:
To evaluate the clinical effectiveness of convalescent plasma (CP) in patients with acute respiratory distress syndrome (ARDS) due to COVID-19.
DESIGN AND SETTING:
Retrospective study conducted at Kayseri City Education and Research Hospital, Kayseri, Turkey.
METHODS:
The case group consisted of adult patients (> 18 years) with ARDS due to COVID-19 who received CP in combination with antiviral and supportive treatment. These patients were compared with others who only received antiviral and supportive treatment.
RESULTS:
During the study period, a total of 30 patients with ARDS due to COVID-19 were included. Eleven patients (36%) received CP in combination with antiviral and supportive treatment, whereas nineteen patients (64%) in the control group only received antiviral and supportive treatment. On admission, the median age, demographic and clinical data and initial laboratory test results were similar between the groups (P > 0.05). On the 14th day of treatment, the laboratory values remained similar between the groups (P > 0.05). The mortality rates were not significantly different between the groups.
CONCLUSION:
CP treatment did not affect mortality or lead to clinical improvement for COVID-19 patients with ARDS.
KEYWORDS (MeSH terms):
COVID-19; Respiratory distress syndrome; COVID-19 serotherapy [supplementary concept]
AUTHORS’ KEYWORDS:
Coronavirus disease 2019; Convalescent plasma; Acute respiratory distress syndrome.