Oxley et al.1515. Oxley TJ, Mocco J, Majidi S, Kellner CP, Shoirah H, Singh IP, et al. Large-vessel stroke as a presenting feature of Covid-19 in the young. N Engl J Med [Internet]. 2020 [cited 2020 June 29];382(20):e60. Available from: https://doi.org/10.1056/NEJMc2009787 https://doi.org/10.1056/NEJMc2009787...
United States |
Large-vessel stroke as a presenting feature of COVID-19 in the young |
N Engl J Med |
Case report |
Five patients |
Age mean: 40 years old |
Clinical data: 60% COVID-19 and stroke; 40% only stroke |
Gender: 80% men |
Evolution: Severe stroke |
Co et al.1616. Co COC, Yu JRT, Laxamana LC, David-Ona DIA. Intravenous thrombolysis for stroke in a COVID-19 positive filipino patient, a case report. J Clin Neurosci [Internet]. 2020 [cited 2020 June 29];77:234-6. Available from: https://doi.org/10.1016/j.jocn.2020.05.006 https://doi.org/10.1016/j.jocn.2020.05.0...
Philippines |
Intravenous thrombolysis for stroke in a COVID-19 positive Filipino patient, a case report |
J Clin Neurosci |
Case report |
One female patient |
Age: 62 years old |
Female gender |
Clinical data: COVID-19 and stroke |
Evolution: acute neurological complications |
Lodigiani et al.1717. Lodigiani C, Lapichino G, Carenzo L, Cecconi M, Ferrazzi P, Sebastian T, et al. Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy. Thromb Res [Internet]. 2020 [cited 2020 June 29];191:9-14. Available from: https://doi.org/10.1016/j.thromres.2020.04.024 https://doi.org/10.1016/j.thromres.2020....
Italy |
Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy |
Thromb Res |
Retrospective Cohort |
388 patients |
Age mean: 66 years old |
Clinical data: 5.2% stroke |
Gender: 68% men and 32% women |
Evolution: thromboembolic complications and DIC* |
Moshayedi et al.1818. Moshayedi P, Ryan TE, Mejia LLP, Nour M, Liebeskind DS. Triage of Acute ischemic stroke in confirmed COVID-19: large vessel occlusion associated with coronavirus infection. Front Neurol [Internet]. 2020 [cited 2020 Jul 19];11:353. Available from: https://doi.org/10.3389/fneur.2020.00353 https://doi.org/10.3389/fneur.2020.00353...
United States |
Triage of Acute ischemic stroke in confirmed COVID-19: large vessel occlusion associated with coronavirus infection |
Front Neurol |
Case report |
One male patient |
Age: 80 years old |
Male gender |
Clinical data: COVID-19 and stroke |
Evolution: intracranial hemorrhage, heart failure, cardiogenic shock and bilateral limb ischemia |
Qureshi et al.1919. Qureshi AI, Abd-Allah F, Al-Senani F, Aytac E, Borhani-Haghighi A, Ciccone A, et al. Management of acute ischemic stroke in patients with COVID-19 infection: report of an international panel. Int J Stroke [Internet]. 2020 [cited 2020 Jul 19];15(5):540-54. Available from: https://doi.org/10.1177/1747493020923234 https://doi.org/10.1177/1747493020923234...
United States |
Management of acute ischemic stroke in patients with COVID-19 infection: report of an international panel |
Int J Stroke |
Theoretical study |
Tunç et al.2020. Tunç A, Ünlübaş Y, Alemdar M, Akyüz E. Coexistence of COVID-19 and acute ischemic stroke report of four cases. J Clin Neurosci [Internet]. 2020 [cited 2020 Jul 19];77:227-9. Available from: https://doi.org/10.1016/j.jocn.2020.05.018 https://doi.org/10.1016/j.jocn.2020.05.0...
Peru |
Coexistence of COVID-19 and acute ischemic stroke report of four cases |
J Clin Neurosci |
Case report |
Four (04) patients |
Age mean: 65 years old |
Gender: 50% men and 50% women |
Clinical data: COVID-19 and stroke 100% |
Evolution: anterior artery infarction and arrhythmia |
Valderrama et al.2121. Valderrama EV, Humbert K, Lord A, Frontera J, Yaghi S. Severe acute respiratory syndrome coronavirus 2 infection and ischemic stroke. Stroke [Internet]. 2020 [cited 2020 Jul 26];51(7):e124-7. Available from: https://doi.org/10.1161/strokeaha.120.030153 https://doi.org/10.1161/strokeaha.120.03...
United States |
Severe acute respiratory syndrome coronavirus 2 infection and ischemic stroke |
Stroke |
Case report |
One male patient |
Age: 52 years old |
Gender: male |
Clinical data: COVID-19 and stroke |
Evolution: hemorrhage |
Rothstein et al.2222. Rothstein A, Oldridge O, Schwennesen H, Do D, Cucchiara BL. Acute Cerebrovascular Events in Hospitalized COVID-19 Patients. Stroke [Internet]. 2020 [cited 2020 Jul 26];51(9):e219-22. https://doi.org/10.1161/strokeaha.120.030995 https://doi.org/10.1161/strokeaha.120.03...
United States |
Acute Cerebrovascular Events in Hospitalized COVID-19 Patients |
Stroke |
Retrospective and observational |
844 patients |
Age mean: 59 years old |
Clinical data: 2.4% ischemic stroke, 0.9% hemorrhagic stroke |
Gender: 52% female |
Outcome: hemorrhages and DIC* |
Lin et al.2323. Lin C, Arevalo YA, Nanavati HD, Lin DM. Racial differences and an increased systemic inflammatory response are seen in patients with COVID-19 and ischemic stroke. Brain Behav Immun Health [Internet]. 2020 [cited 2020 Jul 26];8:100137. Available from: https://doi.org/10.1016/j.bbih.2020.100137 https://doi.org/10.1016/j.bbih.2020.1001...
United States |
Racial differences and an increased systemic inflammatory response are seen in patients with COVID-19 and ischemic stroke |
Brain, Behav Immun Health |
Cross-sectional, observational |
60 patients |
Age mean: 58 years old |
Gender: 55% female |
Clinical data: 15% COVID-19 |
Evolution: increase in mortality and in hospital stay |
Avula et al.2424. Avula A, Nalleballe K, Narula N, Sapozhnikov S, Dandu V, Toom S, et al. COVID-19 presenting as stroke. Brain Behav Immun [Internet]. 2020 [cited 2020 Sept 11];87:115-9. Available from: https://doi.org/10.1016/j.bbi.2020.04.077 https://doi.org/10.1016/j.bbi.2020.04.07...
United States |
COVID-19 presenting as stroke |
Brain, Behav Immun Health |
Retrospective |
Four patients |
Age mean: 81 years old |
Gender: 75% female |
Clinical data: Stroke |
Evolution: neuropsychomotor impairment |
Benussi et al.2525. Benussi A, Pilotto A, Premi E, Libri I, Giunta M, Agosti C, et al. Clinical characteristics and outcomes of inpatients with neurologic disease and COVID-19 in Brescia, Lombardy, Italy. Neurology [Internet]. 2020 [cited 2020 Sept 11];95(7):e910-20. Available from: https://doi.org/10.1212/WNL.0000000000009848 https://doi.org/10.1212/WNL.000000000000...
Italy |
Clinical characteristics and outcomes of inpatients with neurologic disease and COVID-19 in Brescia, Lombardy, Italy |
Neurology |
Retrospective Cohort |
173 patients |
Age mean: 72 years old |
Gender: 53.8% male |
Clinical data: 34.2% stroke |
Evolution: high intra-hospital mortality |
Hernández-Fernández et al.2626. Hernández-Fernández F, Sandoval VH, Barbella-Aponte RA, Collado-Jiménez R, Ayo-Martín Ó, Barrena C, et al. Cerebrovascular disease in patients with COVID-19: neuroimaging, histological and clinical description. Brain [Internet]. 2020 [cited 2020 Sept 11];143(10):3089-103. Available from: https://doi.org/10.1093/brain/awaa239 https://doi.org/10.1093/brain/awaa239...
Spain |
Cerebrovascular disease in patients with COVID-19: neuroimaging, histological and clinical description |
Brain |
Retrospective |
1,683 patients |
Age mean: 67 years old |
Gender: 78% male |
Clinical data: 74.2% stroke |
Evolution: hypercoagulability and systemic complications |
Grewal et al.2727. Grewal P, Pinna P, Hall JP, Dafer RM, Tavarez T, Pellack DR, et al. Acute ischemic stroke and COVID-19: experience from a comprehensive stroke center in Midwest US. Front Neurol [Internet]. 2020 [cited 2020 Sept 11];11:910. Available from: https://doi.org/10.3389/fneur.2020.00910 https://doi.org/10.3389/fneur.2020.00910...
United States |
Acute Ischemic Stroke and COVID-19: Experience from a Comprehensive Stroke Center in Midwest US |
Frontiers in Neurology |
Retrospective and observational |
650 patients |
Age mean: 61 years old |
Gender: 46% male |
Clinical data: 2% stroke |
Evolution: high inflammatory activity and coagulability markers |
Hanif et al.2828. Hanif A, Khan S, Mantri N, Hanif S, Saleh M, Alla Y, et al. Thrombotic complications and anticoagulation in COVID-19 pneumonia: a New York City hospital experience. Ann Hematol [Internet]. 2020 [cited 2020 Sept 11];99(10):2323-8. Available from: https://doi.org/10.1007/s00277-020-04216-x https://doi.org/10.1007/s00277-020-04216...
United States |
Thrombotic complications and anticoagulation in COVID-19 pneumonia: a New York City hospital experience |
Ann Hematol Oncol |
Retrospective |
1,308 patients |
Age mean: 62 years old |
Gender: 62.3% male |
Clinical data: 1.19% stroke |
Evolution: need for transfusional support and death |
Jain et al.2929. Jain R, Young M, Dogra S, Kennedy H, Nguyen V, Jones S, et al. COVID-19 related neuroimaging findings: A signal of thromboembolic complications and a strong prognostic marker of poor patient outcome. J Neurol Sci [Internet]. 2020 [cited 2020 Sept 11];414:116923. Available from: https://doi.org/10.1016/j.jns.2020.116923 https://doi.org/10.1016/j.jns.2020.11692...
United States |
COVID-19 related neuroimaging findings: A signal of thromboembolic complications and a strong prognostic marker of poor patient outcome |
J Neurol Sci |
Retrospective |
3,218 patients |
Age mean: 66 years old |
Gender: 60.7% male |
Clinical data: 1.1% stroke |
Evolution: intracranial hemorrhage and death |
Yaghi et al.3030. Yaghi S, Ishida K, Torres J, Grory BM, Raz E, Humbert K, et al. SARS-CoV-2 and stroke in a New York healthcare system. Stroke [Internet]. 2020 [cited 2020 Sept 18];51:2002-11. Available from: https://doi.org/10.1161/strokeaha.120.030335 https://doi.org/10.1161/strokeaha.120.03...
United States |
SARS-CoV-2 and Stroke in a New York Healthcare System |
Stroke |
Retrospective and observational |
3,556 patients |
Age mean: 63 years old |
Gender: 71.9% male |
Clinical data: 0.9% stroke |
Evolution: elevated D-dimer and high mortality |
Shahjouei et al.3131. Shahjouei S, Naderi S, Li J, Khan A, Chaudhary D, Farahmand G, et al. Risk of stroke in hospitalized SARS-CoV-2 infected patients: a multinational study. EBioMedicine [Internet]. 2020 [cited 2020 Sept 18];59:102939. Available from: https://doi.org/10.1016/j.ebiom.2020.102939 https://doi.org/10.1016/j.ebiom.2020.102...
Spain |
Risk of stroke in hospitalized SARS-CoV-2 infected patients: A multinational study |
EBioMedicine |
Observational, multicentric and multinational |
26,175 patients |
Age mean: 67 years old |
Gender: 47% female |
Clinical data: 0.9% stroke |
Evolution: need for mechanical ventilation and ischemic heart problems |
Liu et al.3232. Liu J, Zhang S, Wu Z, Shang Y, Dong X, Li G, et al. Clinical outcomes of COVID-19 in Wuhan, China: a large cohort study. Ann Intensive Care [Internet]. 2020 [cited 2020 Sept 21];10(1):99. Available from: https://doi.org/10.1186/s13613-020-00706-3 https://doi.org/10.1186/s13613-020-00706...
Germany |
Clinical outcomes of COVID-19 in Wuhan, China: a large cohort study |
Ann Intensive Care |
Retrospective Cohort |
1,190 patients |
Age mean: 57 years old |
Gender: 46.6% female |
Clinical data: 3.3% stroke |
Evolution: need for mechanical ventilation and intra-hospital death |
Yamakawa et al.3333. Yamakawa M, Kuno T, Mikami T, Takagi H, Gronseth G. Clinical characteristics of stroke with COVID-19: a systematic review and meta-analysis. J Stroke Cerebrovasc Dis [Internet]. 2020 [cited 2020 Sept 18];29(12):105288. Available from: https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.105288 https://doi.org/10.1016/j.jstrokecerebro...
United Kingdom |
Clinical Characteristics of Stroke with COVID-19: A Systematic Review and Meta-Analysis |
Int J Stroke Cerebrovasc. Dis |
Theoretical |
215 articles |
4.6% stroke |
Zhang et al.3434. Zhang L, Sun W, Wang Y, Wang X, Liu Y, Zhao S, et al. Clinical course and mortality of stroke patients with coronavirus disease 2019 in Wuhan, China. Stroke [Internet]. 2020 [cited 2020 Sept 18];51(9):2674-82. Available from: https://doi.org/10.1161/strokeaha.120.030642 https://doi.org/10.1161/strokeaha.120.03...
United States |
Clinical Course and Mortality of Stroke Patients with Coronavirus Disease 2019 in Wuhan, China |
Stroke |
A series of unicentric cases |
709 patients |
Age mean: 55 years old |
Gender: 45% male |
Clinical data: 8% stroke |
Evolution: high mortality |
Siegler et al.3535. Siegler JE, Cardona CP, Arenillas JF, Talavera B, Guillen AN, Chavarría-Miranda A, et al. Cerebrovascular events and outcomes in hospitalized patients with COVID-19: The SVIN COVID-19 Multinational Registry. Int J Stroke [Internet]. 2020 [cited 2020 Sept 18];16(4):437-47. Available from: https://doi.org/10.1177/1747493020959216 https://doi.org/10.1177/1747493020959216...
United States |
Cerebrovascular events and outcomes in hospitalized patients with COVID-19: The SVIN COVID-19 Multinational Registry |
Int l J Stroke |
Observational and retrospective cohort study |
14,483 patients |
Age mean: 60 years old |
Gender: 55.8% female |
Clinical data: 1.13% stroke |
Evolution: long-term thrombotic complications |
Studart-neto et al.3636. Studart-Neto A, Guedes BF, Tuma RL, Camelo FAE, Kubota GT, Lepsen BD, et al. Neurological consultations and diagnoses in a large, dedicated COVID-19 university hospital. Arq Neuropsiquiatr [Internet]. 2020 [cited 2020 Sept 18];78(8):494-500. Available from: https://doi.org/10.1590/0004-282x20200089 https://doi.org/10.1590/0004-282x2020008...
Brazil |
Neurological consultations and diagnoses in a large, dedicated COVID-19 university hospital |
Arq Neuropsiquiatria |
Retrospective study |
1,208 patients |
Age mean: 57 years old |
Gender: 61.8% male |
Clinical data: 16.7% stroke |
Evolution: severe neurological complications, respiratory failure and death |
Teo et al.3737. Teo KC, Leung WCY, Wong YK, Liu RKC, Chan AHY, Choi OMY, et al. Delays in stroke onset to hospital arrival time during COVID-19. Stroke [Internet]. 2020 [cited 2020 Sept 18];51(7):2228-31. Available from: https://doi.org/10.1161/strokeaha.120.030105 https://doi.org/10.1161/strokeaha.120.03...
United States |
Delays in Stroke Onset to Hospital Arrival Time During COVID-19 |
Stroke |
Retrospective study |
386 patients |
Age mean: 70 years old |
Gender: 43.8% male |
Clinical data: 9.1% stroke |
Evolution: increase in mortality |
Nguyen-Huynh et al.3838. Nguyen-Huynh MN, Tang XN, Vinson DR, Flint AC, Alexander JG, Meighan M, et al. Acute stroke presentation, care, and outcomes in community hospitals in Northern California during the COVID-19 pandemic. Stroke [Internet]. 2020 [cited 2020 Sept 18];51(10):2918-24. Available from: https://doi.org/10.1161/strokeaha.120.031099 https://doi.org/10.1161/strokeaha.120.03...
United States |
Acute Stroke Presentation, Care, and Outcomes in Community Hospitals in Northern California During the COVID-19 Pandemic |
Stroke |
Cohort study |
9,120 patients |
Age mean: 65 years old |
Gender: 52.9% female |
Clinical data: 11.6% stroke |
Evolution: increase in mortality |