França1010. Rouget F, Kadhel P, Monfort C, Viel JF, Thome JP, Cordier S, et al. Chlordecone exposure and risk of congenital anomalies: the Timoun Mother-Child Cohort Study in Guadeloupe (French West Indies). Environ Sci Pollut Res Int [Internet]. 2020 Nov [cited 2020 Jul 06];27(33):40992-8. Available from: https://doi.org/10.1007/s11356-019-06031-y https://doi.org/10.1007/s11356-019-06031...
|
coorte |
1.068 grávidas |
Malformações do sistema reprodutor |
IV |
Brasil88. Gaspari L, Sampaio DR, Paris F, Audran F, Orsini M, Neto JB, Sulatn C. High prevalence of micropenis in 2710 male newborns from na intensive-use pesticide area of Northeastern Brazil. Int J Androl [Internet]. 2012 [cited 2020 Jul 6];35(3):253-64. Available from: https://doi.org/10.1111/j.1365-2605.2011.01241.x https://doi.org/10.1111/j.1365-2605.2011...
|
coorte |
2710 nascidos masculinos |
Criptorquidia, hipospádia e micropênis |
IV |
França2727. Chevrier C, Limon G, Monfort C, Rouget F, Garlantézec R, Petit C, et al. Urinary biomarkers of prenatal atrazine exposure and adverse birth outcomes in the PELAGIE birth cohort. Environ Health Perspect [Internet]. 2011 [cited 2020 Jul 03];119(7):1034-41. Available from: https://doi.org/doi:10.1289/ehp.1002775 https://doi.org/doi:10.1289/ehp.1002775...
|
coorte |
579 mulheres grávidas |
Restrição do crescimento fetal |
IV |
EUA1919. Addissie YA, Kruszka P, Troia A, Wong ZC, Everson JL, Kozel BA, et al. Prenatal exposure to pesticides and risk for holoprosencephaly: a case control study. Environ Health [Internet]. 2020 [cited 2020 Dec 08];19(1):65. Available from: https://doi.org/10.1186/s12940-020-00611-z https://doi.org/10.1186/s12940-020-00611...
|
caso controle |
92 casos e 56 controles |
Holoprosencefalia |
IV |
EUA1111. Axelsson J, Scott K, Dillner J, Lindh CH, Zhang H, Rylander L, et al. Exposure to polychlorinated compounds and cryptorchidism; A nested case-control study. PLoS One [Internet]. 2020 Jul 23 [cited 2020 Dec 08];15(7):e0236394. Available from: https://doi.org/10.1371/journal.pone.0236394 https://doi.org/10.1371/journal.pone.023...
|
caso controle |
165 casos e 165 controles |
Criptorquidia |
IV |
EUA2424. Pettigrew SM, Bell EM, Van Zutphen AR, Rocheleau CM, Shaw GM, Romitti PA, et al. Paternal and joint parental occupational pesticide exposure and spina bifida in the National Birth Defects Prevention Study, 1997 to 2002. Birth Defects Res A Clin Mol Teratol [Internet]. 2016 [cited 2020 Jul 06];106(11):963-71. Available from: https://doi.org/10.1002/bdra.23551 https://doi.org/10.1002/bdra.23551...
|
caso controle |
291 casos para 2745 controles |
Espinha bífida |
IV |
EUA1717. Winston JJ, Emch M, Meyer RE, Langlois P, Weyer P, Mosley B, et al. Hypospadias and maternal exposure to atrazine via drinking water in the National Birth Defects Prevention study. Environ Health [Internet]. 2016 [cited 2020 Jul 06];15(1):76. Available from: https://doi.org/10.1186/s12940-016-0161-9 https://doi.org/10.1186/s12940-016-0161-...
|
caso controle |
343 casos de hipospádia e 1.422 controles masculinos |
Hipospádia |
IV |
EUA2929. Agopian AJ, Cai Y, Langlois PH, Canfield MA, Lupo PJ. Maternal residential atrazine exposure and risk for choanal atresia and stenosis in offspring. J Pediatr [Internet]. 2013 [cited 2020 Jul 6];162(3):581-6. Available from: https://doi.org/10.1016/j.jpeds.2012.08.012 https://doi.org/10.1016/j.jpeds.2012.08....
|
caso controle |
372 casos para 3720 controles. |
Atresia ou estenose coanal |
IV |
EUA2626. Kielb C, Lin S, Herdt-Losavio M, Bell E, Chapman B, Rocheleau CM, et al. Maternal periconceptional occupational exposure to pesticides and selected musculoskeletal birth defects. Int J Hyg Environ Health [Internet] 2014 [cited 2020 Jul 06];217(2-3):248-54. Available from: https://doi.org/10.1016/j.ijheh.2013.06.003 https://doi.org/10.1016/j.ijheh.2013.06....
|
caso controle |
871 casos e 2857 controles |
Craniossinostose, gastrosquise, hérnia diafragmático e deficiências transversais dos membros |
IV |
EUA2121. Makelarski JA, Romitti PA, Rocheleau CM, Burns TL, Stewart PA, Waters MA, et al. Maternal periconceptional occupational pesticide exposure and neural tube defects. Birth Defects Res A Clin Mol Teratol [Internet]. 2014 [cited 2020 Jul 06];100(11):877-86. Available from: https://doi.org/10.1002/bdra.23293 https://doi.org/10.1002/bdra.23293...
|
caso controle |
502 casos e 2950 controles |
Defeitos no tubo neural |
IV |
EUA2323. Yang W, Carmichael SL, Roberts EM, Kegley SE, Padula AM, English PB, et al. Residential agricultural pesticide exposures and risk of neural tube defects and orofacial clefts among offspring in the San Joaquin Valley of California. Am J Epidemiol [Internet]. 2014 [cited 2020 Jul 06];179(6):740-8. Available from: https://doi.org/10.1093/aje/kwt324 https://doi.org/10.1093/aje/kwt324...
|
caso controle |
367 casos e 785 controles |
Anencefalia, espinha bífida com e sem fenda palatina |
IV |
EUA3232. Shaw GM, Yang W, Roberts E, Kegley SE, Padula A, English PB, Carmichael SL. Early pregnancy agricultural pesticide exposures and risk of gastroschisis among offspring in the San Joaquin Valley of California. Birth Defects Res A Clin Mol Teratol [Internet]. 2014 [cited 2020 Jul 06];100(9):686-94. Available from: https://doi.org/10.1002/bdra.23263 https://doi.org/10.1002/bdra.23263...
|
caso controle |
156 casos para 785 controles |
Gastrosquise |
IV |
EUA1515. Rocheleau CM, Romitti PA, Sanderson WT, Sun L, Lawson CC, Waters MA, et al. Maternal occupational pesticide exposure and risk of hypospadias in the National birth defects prevention study. Birth Defects Res A Clin Mol Teratol [Internet]. 2011 [cited 2020 Jul 06];91(11):927-36. Available from: https://doi.org/10.1002/bdra.22860 https://doi.org/10.1002/bdra.22860...
|
caso controle |
646 casos e 1493 controles |
Hipospádia |
IV |
EUA77. Carmichael SL, Herring AH, Sjödin A, Jones R, Larry N, Ma C, et al. Hypospadias and halogenated organic pollutant levels in maternal mid-pregnancy serum samples. Chemosphere [Internet]. 2010 [cited 2020 Jul 06]; 80(6):641-6. Available from: https://doi.org/10.1016/j.chemosphere.2010.04.055 https://doi.org/10.1016/j.chemosphere.20...
|
caso controle |
20 casos e 28 controles |
hipospadia |
IV |
EUA3333. Waller SA, Paul K, Peterson SE, Hitti JE. Agricultural-related chemical exposures, season of conception, and risk of gastroschisis in Washington State. Am J Obstet Gynecol [Internet]. 2010 [cited 2020 Jul 06];202(3): p241.e1-241.e6. Available from: https://doi.org/10.1016/j.ajog.2010.01.023 https://doi.org/10.1016/j.ajog.2010.01.0...
|
caso controle |
4 controles para um caso sendo 805 casos para 3616 controles |
Gastrosquise e defeitos da parede abdominal |
IV |
Brasil2525. Oliveira NP, Moi GP, Atanaka-Santos M, Silva AMC, Pignati WA. Malformações congênitas em municípios de grande utilização de agrotóxicos em Mato Grosso, Brasil. Ciênc Saúde Coletiva [Internet]. 2014 [cited 2020 Jul 06];19(10):4123-30. Available from: https://doi.org/10.1590/1413-812320141910.08512014 https://doi.org/10.1590/1413-81232014191...
|
caso controle |
219 casos para 862 controles |
Malformações congênitas |
IV |
Brasil3838. Ueker ME, Silva VM, Moi GP, Pignati WA, Mattos IE, Silva AMC. Parenteral exposure to pesticides and occurence of congenital malformations: hospital-based case-control study. BMC Pediatr [Internet]. 2016 [cited 2020 Jul 06];16(1):125. Available from: https://doi.org/10.1186/s12887-016-0667-x https://doi.org/10.1186/s12887-016-0667-...
|
caso controle |
137 casos para 274 controles |
< 5 anos com malformações congênitas |
IV |
Brasil e Índia2020. Kalra S, Dewan P, Batra P, Sharma T, Tyagi V, Banerjee BD. Organochlorine pesticide exposure in mothers and neural tube defects in offsprings. Reprod Toxicol [Internet]. 2016 [cited 2020 Jul 06];66:56-60. Available from: https://doi.org/10.1016/j.reprotox.2016.09.005 https://doi.org/10.1016/j.reprotox.2016....
|
caso controle |
35 casos 35 controles (mãe e bebê) |
Anomalia congênita devido a defeitos no tubo neural |
IV |
Índia1616. ShekharYadav C, Bajpai M, Kumar V, Ahmed RS, Gupta P, Banerjee BD. Polymorphism in CYP1A1, GSTMI, GSTT1 genes and organochlorine pesticides in the etiology of hypospadias. Hum Exp Toxicol [Internet] 2011 [cited 2020 Jul 06];30(10):1464-74. Available from: https://doi.org/10.1177/0960327110392402 https://doi.org/10.1177/0960327110392402...
|
caso controle |
80 meninos com hipospádia e 120 controles |
Hipospádia |
IV |
Índia3131. Sharma E, Mustafa M, Pathak R, Ahmed RS, Vaid NB, Baneriee BD. A case control study of gene environmental interaction in fetal growth restriction with special reference to organochlorine pesticides. Eur J Obstet Gynecol Reprod Biol [Internet]. 2012 [cited 2020 Jul 06];161(2):163-9. Available from: https://doi.org/10.1016/j.ejogrb.2012.01.008 https://doi.org/10.1016/j.ejogrb.2012.01...
|
caso controle |
casos de restrição de crescimento fetal: 50; controle: 50 |
Restrição no crescimento fetal |
IV |
França1414. Morera AM, Valmalle AF, Asensio MJ, Chauvin MA, Durand P. A study of risk factors for hypospadias in the Rhône-Alpes region (France). J Pediatr Urol [Internet] 2006 [cited 2020 Jul 06];2(3):169-77. Available from: https://doi.org/10.1016/j.jpurol.2005.09.008 https://doi.org/10.1016/j.jpurol.2005.09...
|
caso controle |
225 casos de hipospádia e 225 controles |
Hipospádia |
IV |
Holanda3636. Spinder N, Bergman JEH, Kromhout H, Vermeulen R, Corsten-Janssen N, Boezen HM, et al. Maternal occupational exposure and congenital heart defects in offspring. Scand J Work Environ Health [Internet]. 2020 [cited 2020 Dec 4];46(6):588-608. Available from: https://doi.org/10.5271/sjweh.3912 https://doi.org/10.5271/sjweh.3912...
|
caso controle |
1174 casos e 5602 controles |
Doenças cardíacas congênitas |
IV |
Holanda3737. Spinder N, Bergman JE, Boezen HM, Vermeulen RC, Kromhout H, Walle HE. Maternal occupational exposure and oral clefts in offspring. Environ Health [Internet] 2017 [cited 2020 Jul 06]; 16:83. Available from: https://doi.org/10.1186/s12940-017-0294-5 https://doi.org/10.1186/s12940-017-0294-...
|
caso controle |
casos 387 foram definidos como fendas não sindrômicas, 1135 cromossômicos e 4352 controles não-cromossômicos malformados |
Fendas labiais |
IV |
México1313. Montes LPB, WaliszewskiII S, Hernández-ValeroIII M, Sanín-Aguirre L, Infanzón-Ruiz R, Jañas AG. Exposición prenatal a los plaguicidas organoclorados y criptorquidia. Ciênc Saúde Coletiva [Internet]. 2010 [cited 2020 Jul 06];15(Suppl 1):1169-74. Available from: https://doi.org/10.1590/S1413-81232010000700025 https://doi.org/10.1590/S1413-8123201000...
|
caso controle |
Binômio mãe -bebê Caso recém-nascidos com diagnóstico de criptorquidia (n=41). Controles 41 com testículos decíduos |
Criptorquidia |
IV |
México1818. Brender JD, Felkner M, Suarez L, Canfield MA, Henry JP. Maternal pesticide exposure and neural tube defects in Mexican Americans. Ann Epidemiol. [Internet]. 2010 [cited 2020 Jul 06];20(1):16-22. Available from: https://doi.org/10.1016/j.annepidem.2009.09.011 https://doi.org/10.1016/j.annepidem.2009...
|
caso controle |
184 mulheres de casos e 225 mulheres de controles |
Defeitos no tubo neural |
IV |
Etiópia3535. Mekonnen AG, Hordofa AG, Kitila TT, Sav A. Modifiable risk factors of congenital malformations in bale zone hospitals, Southeast Ethiopia: an unmatched case-control study. BMC Pregnancy Childbirth [Internet]. 2020 [cited 2020 Dec 04];20(1):129. Available from: https://doi.org/10.1186/s12884-020-2827-0 https://doi.org/10.1186/s12884-020-2827-...
|
caso controle |
136 casos e 273 controle |
Malformações congênitas |
IV |
Hungria3434. Fazekas-Pongor V, Csáky-Szunyogh M, Fekete M, Mészáros A, Cseh K, Pénzes M. Congenital heart diseases and parental occupational exposure in a Hungarian case-control study in 1997 to 2002. Congenit Anom (Kyoto) [Internet]. 2021 Mar [cited 2020 Dec 04];61(2):55-62. Available from: Available from: Available from: https://doi.org/10.1111/cga.12401. https://doi.org/10.1111/cga.12401....
|
caso controle |
2.263 casos e 6.789 controles |
Doenças cardíacas congênitas |
IV |
Paraguai3030. Ojeda CL, Leite SB. Factores de riesgo prenatales y su asociación a malformaciones congénitas en un hospital universitario de referência. Pediatr (Asunción) [Internet]. 2018 [cited 2020 Jul 06];45(1):8-16. Available from: https://doi.org/10.31698/ped.45012018002 https://doi.org/10.31698/ped.45012018002...
|
caso controle |
66 casos e 66 controles |
Malformações congênitas |
IV |
Grécia1212. Michalakis M, Tzatzarakis MN, Kovatsi L, Alegakis KA, Tsakalof AK, Heretise I, et al. Hypospadias in offspring is associated with chronic exposure of parents to organophosphate and organochlorine pesticides. Toxicol Lett [Internet] 2014 [cited 2020 Jul 06];230(2):139-45. Available from: https://doi.org/10.1016/j.toxlet.2013.10.015 https://doi.org/10.1016/j.toxlet.2013.10...
|
caso controle |
29 crianças com hipospádia e 49 pais. |
Hipospádia |
IV |
Egito2828. El-Helaly M, Abdel-Elah K, Haussein A, Shalaby H. Paternal occupational exposures and the risk of congenital malformations--a case-control study. Int J Occup Med Environ Health [Internet] 2011 [cited 2020 Jul 06];24(2):218-27. Available from: https://doi.org/10.2478/s13382-011-0019-x https://doi.org/10.2478/s13382-011-0019-...
|
caso controle |
242 casos de malformações congênitas e 270 controles |
Malformações congênitas |
IV |
China2222. Ren A, Qiu X, Jin L, Ma J, Zhiwen L, Zhang L, et al. Association of selected persistent organic pollutants in the placenta with the risk of neural tube defects. Proc Natl Acad Sci USA [Internet]. 2011 [cited 2020 Jul 06];108(31):12770-5. Available from: https://doi.org/10.1073/pnas.1105209108 https://doi.org/10.1073/pnas.1105209108...
|
caso controle |
80 fetos ou recém-nascidos com DTN, enquanto os controles foram 50 recém-nascidos saudáveis |
Defeitos no tubo neural (DTN) |
|
Itália99. Giordano F, Abballe A, De Felip E, di Domenico A, Ferro F, Grammatico P et al. Maternal exposures to endocrine disrupting chemicals and hypospadias in offspring. Birth Defects Res A Clin Mol Teratol [Internet] 2010 [cited 2020 Jul 6];88(4):241-50. Available from: https://doi.org/10.1002/bdra.20657 https://doi.org/10.1002/bdra.20657...
|
caso controle |
80 mães com bebês com hipospádia e de 80 mães com controles saudáveis |
Hipospádia |
IV |