ABSTRACT
This work studies the growing of tumoral cells taking into account the microenvironmental between effector cell, anti inflammatory cytokines and the immunosuppressive factor. It is presented two variants for the math models of(1) by inserting a switching term on these. Also, it is done a qualitative study of the models and by the stability analysis and the numerical development work, we showed the results of this research.
Keywords:
mathematical modelling; imunotherapy; existence and uniqueness; stabilty analysis