Pituitary adenomas: clinical, surgical, immunohistochemical aspects, invasive and proliferative cellular nuclear antigen (PCNA) relationship

PITUITARY ADENOMAS: CLINICAL, SURGICAL, IMMUNOHISTOCHEMICAL ASPECTS, INVASIVE AND PROLIFERATIVE CELLULAR NUCLEAR ANTIGEN (PCNA) RELATIONSHIP (ABSTRACT).^*. THESIS. SÃO PAULO, 2000.

OSWALDO INÁCIO DE TELLA JR.^**

The author evaluated clinically, radiologically and surgically a series of 76 pituitary adenomas. All cases were assessed immunohistochemically and in 49 patients the PCNA monoclonal antibody was measured.

The most frequent types found were the bihormonal adenomas, followed by prolactinomas and non secreting adenomas. The bihormonal adenomas, non secreting adenonas and the sub unit alpha producing adenomas were proportionally more invase as determined by radiological criteria (CT scan or MRI).

In 59 patients a transphenoidal approach was used, six cases were operated on transcranially and in 11 patients a combination of both approaches was used. Total resection was achieved in 32 cases, most of which were microadenomas; in 15 cases the resection was subtotal and partial in 29 cases.

Diabetes insipidus was the most frequent endocrine complication.

It was observed that secreting adenomas tend to be associated with an increased PCNA and invasive adenomas correlated with PCNA 3 and 4.

An improvement in vision was observed in 85% of macroadenomas seen after a total, subtotal or partial resection.

KEY WORDS: pituritary gland, transphenoidal surgery, adenoma, immunohistochemistry, PCNA.

**Address: Rua São Paulo Antigo 145 Bloco F Apto 11, 05864-010 São Paulo SP, Brasil. E-mail: [e-mail]

*

Adenomas hipofisários: relação entre os aspectos clínicos, cirúrgicos, imuno-histoquímicos,invasividade e índice proliferativo tumoral (PCNA) (Resumo). Tese de Livre Docência. Universidade Federal de São Paulo ¾ Escola Paulista de Medicina (Área: Neurocirurgia).

Publication Dates

• Publication in this collection
  11 Apr 2002
• Date of issue
  Mar 2002