The trajetory of leprosy and lepers in the Medieval period is a special subject to the study of the impact of a disease on a determined society, and of the social mechanisms implicated on the perception, delimitation, and destiny of the diseases, for it achieved the Medieval Occident in a time when it was defining itself in an excluding way in relation to a change. The mechanisms that the Middle Ages created to overcome the desestabilization caused by the forthcoming of leprosy, keeping the lepefs away from the social contact, and locking them in a world apart, that caused fear, suspicion, and hate at the same time, were very well accepted by the society. Therefore, during a long time, the segregation, and confinment that were fixed around the lepers appeared in the treatment that occidental society gave to its social outcasts; moreover, the occidental medicine itself incorporated them as base for the therapeutic action, in which the segregation of pacients became the compulsory way to cure.