Preclinical evidence of antinociceptive action of 3-phenyl-5-(4-etilfenil)-imidazolidine-2,4-dione in psychopharmacological studies

THESES

Preclinical evidence of antinociceptive action of 3-phenyl-5-(4-etilfenil)-imidazolidine-2,4-dione in psychopharmacological studies (Abstract)^*. Dissertation. João Pessoa, 2011

Ronaldo Bezerra de Queiroz^**

Imidazolidine derivatives are synthetic products with many different therapeutic applications. The 3-phenyl-5-(4-ethyphenyl)-imidazolidine-2,4-dione (IM-3), recently synthesized from amino acid was selected for psychopharmacological studies. The study has began with screening and behavioral pharmacology of the LD₅₀ determination. In the screening results indicate a depressant activity on CNS and from the LD₅₀ doses were chosen for subsequent tests with 50, 100 and 200 mg/kg intraperitoneally. In the next step, methodologies to evaluate the specific antinociceptive activity were used. The first was the writhing induced by acetic acid; afterwards, the formalin test and finally the hot plate test, which is specific for the central antinociceptive activity. In the three methodologies used, the IM-3 showed to be effective in the writhing test by acetic acid at a dose of 200 mg/kg which increased both the latency to the onset of writhing and reduced the number of writhing in the control group and in the formalin test at doses of 100 and 200 mg/kg decreased the time of the paw lick in the second phase of testing. Therefore, from these experimental data, it is possible to infer that the IM-3 has antinociceptive activity of the anti-inflammatory type.

Key words: imidazolidine derivatives, psychopharmacology, antinociceptive, anti inflammatory activity.

**

Evidências pré-clínicas da ação antinociceptiva do 3-fenil-5-(4-etilfenil)-imidazolidina-2,4-diona em estudos psicofarmacológicos (Resumo). Dissertação de Mestrado. Centro de Ciências da Saúde da Universidade Federal da Paraíba, João Pessoa PB (Área: Farmacologia). Orientadora: Liana Clébia Soares Lima de Morais, Co-Orientador: Reinaldo Nóbrega de Almeida.

Publication Dates

• Publication in this collection
  01 Sept 2011
• Date of issue
  Aug 2011