Copper and ceruloplasmin contents in the blood serum of peripheral and pre-hepatic veins

Canelas, H. M.; Roitman, I.; Scaff, M.; Raia, S.; De Jorge, F. B.

doi:10.1590/S0004-282X1976000100005

Abstracts

Copper and ceruloplasmin contents were determined in samples of peripheral and pre-hepatic venous blood of 11 patients with Manson's schistosomiasis and one patient with hepatolenticular degeneration, all of çhich submitted either to porto-caval or spleno-renal shunt. Individual difference were not significant in any of the non-Wilsonian patients. The results are discussed in regard to the current knowledge on the pathogenesis of Wilson's disease.

Foram determinadas as concentrações de cobre e ceruloplasmina em amostras de sangue venoso periférico e pré-hepático de 11 pacientes esquistossomóticos e de 1 paciente com degeneração hepatolenticular, submetidos a anastomose portocava ou esplenorrenal. Nos 11 pacientes não wilsonianos, as diferenças individuais não se revelaram estatisticamente significantes. Os resultados são comentados em relação aos conhecimentos atuais sobre a patogenia da moléstia de Wilson.

Copper and ceruloplasmin contents in the blood serum of peripheral and pre-hepatic veins

Concentrações de cobre e ceruloplasmina no soro sanguíneo de veias periférica e pré-hepática

H. M. Canelas; I. Roitman; M. Scaff; S. Raia; F. B. De Jorge

Departments of Neuropsychiatry (Division of Neurology) and Surgery (3^rd Division) of the University of São Paulo Medical School

SUMMARY

Copper and ceruloplasmin contents were determined in samples of peripheral and pre-hepatic venous blood of 11 patients with Manson's schistosomiasis and one patient with hepatolenticular degeneration, all of çhich submitted either to porto-caval or spleno-renal shunt. Individual difference were not significant in any of the non-Wilsonian patients. The results are discussed in regard to the current knowledge on the pathogenesis of Wilson's disease.

RESUMO

Foram determinadas as concentrações de cobre e ceruloplasmina em amostras de sangue venoso periférico e pré-hepático de 11 pacientes esquistossomóticos e de 1 paciente com degeneração hepatolenticular, submetidos a anastomose portocava ou esplenorrenal. Nos 11 pacientes não wilsonianos, as diferenças individuais não se revelaram estatisticamente significantes. Os resultados são comentados em relação aos conhecimentos atuais sobre a patogenia da moléstia de Wilson.

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Departamento de Neuropsiquiatria, Divisão de Neurologia Faculdade de Medicina, Universidade ãe São Paulo Caixa Postal 3461 01000 São Paulo, SP Brasil.

1. BERNSTEIN, L. & WEATHERALL, M. Statistics for Medical and other Biological Students. Livingstone, Edinburgh, 1952, pp. 85-88.
2. DE JORGE, F. B. & CANELAS, H. M. Contribuição ao estudo da ceruloplasmina: valores normais no soro sanguíneo. Arq. Neuro-Psiquiat (São Paulo) 22:271, 1964.
3. DE JORGE, F. B.; CANELAS, H. M. & COSTA-SILVA, A. Contribuição ao estudo do metabolismo do cobre: metodologia da determinação do cobre em materiais biológicos. Rev. paul. Med. 61:350, 1962.
4. DE JORGE, F. B.; CANELAS, H. M. & SPINA-FRANÇA, A. Contribuição ao estudo do metabolismo do cobre: valores normais no sangue, liquido cefalorraqueano e urina. Rev. paul. Med. 62:125, 1963.
5. FROMMER, D. J. Defective biliary excretion of copper in Wilson's disease. Gut 15:125, 1974.
6. GOLDSTEIN, W. P. & OWEN, C. A. Introduction. Symposium of copper metabolism and Wilson's disease. Mayo Clin. Proc. 49:363, 1974.
7. HOUCHIN, O. B. A rapid colorimetric method for the quantitative determination of copper oxidase activity (ceruloplasmin). Clin. Chem. 4:519, 1958.
8. O'REILLY, S. Problems in Wilson's disease. Neurology (Minneapolis) 17: 137, 1967.
9. O'REILLY, S.; POLLYCOVE, M.; TONO, M. & HERRADORA, L. Abnormalities of the physiology of copper in Wilson's disease: the internal kinetics of copper. Arch. Neurol. (Chicago) 24:481, 1971.
10. O'REILLY, S.; WEBER, P. M.; OSWALD, M. & SHIPLEY, L. Abnormalities of the physiology of copper in Wilson's disease: the excretion of copper. Arch. Neurol. (Chicago) 25:28, 1971.
11. OSBORN, S. & WALSHE, J. M. Copper uptake by the liver: study of a Wilson's disease family. In J. M. Walshe & J. N. Cumings Wilson's Disease, Some Current Concepts. Blackwell, Oxford, 1961, p. 141.
12. SASS-KORTSAK, A.; CHERNIAK, M.; GEIGER, D. W. & SLATER, R. J. Observations on ceruloplasmin in Wilson's disease. J. clin. Invest. 38:1672, 1959.
13. SCHEINBERG, I. H. & MORELL, A. G. Ceruloplasmin. In G. Eichhorn Inorganic Biochemistry. Elsevier, Amsterdam, 173, vol. 1, chapter 10, p. 306.
14. TRIP, J. A. J. Ceruloplasmin: Clinical and Experimental Investigations on Origin, Presence and Behavior of Fractions. Wolters-Noorhoff, Groningen, 1968.
15. WALSHE, J. M. The physiology of copper in man and its relation to Wilson's disease. Brain 90:149, 1967.
16. ZIMDAHL, W. T.; HYMAN, I. & COOK, E. D. Metabolism of copper in hepatolenticular degeneration. Neurology (Minneapolis) 3:569, 1953.

Publication Dates

Publication in this collection
14 Mar 2013
Date of issue
Mar 1976

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[1] 1. BERNSTEIN, L. & WEATHERALL, M. Statistics for Medical and other Biological Students. Livingstone, Edinburgh, 1952, pp. 85-88.

[2] 2. DE JORGE, F. B. & CANELAS, H. M. Contribuição ao estudo da ceruloplasmina: valores normais no soro sanguíneo. Arq. Neuro-Psiquiat (São Paulo) 22:271, 1964.

[3] 3. DE JORGE, F. B.; CANELAS, H. M. & COSTA-SILVA, A. Contribuição ao estudo do metabolismo do cobre: metodologia da determinação do cobre em materiais biológicos. Rev. paul. Med. 61:350, 1962.

[4] 4. DE JORGE, F. B.; CANELAS, H. M. & SPINA-FRANÇA, A. Contribuição ao estudo do metabolismo do cobre: valores normais no sangue, liquido cefalorraqueano e urina. Rev. paul. Med. 62:125, 1963.

[5] 5. FROMMER, D. J. Defective biliary excretion of copper in Wilson's disease. Gut 15:125, 1974.

[6] 6. GOLDSTEIN, W. P. & OWEN, C. A. Introduction. Symposium of copper metabolism and Wilson's disease. Mayo Clin. Proc. 49:363, 1974.

[7] 7. HOUCHIN, O. B. A rapid colorimetric method for the quantitative determination of copper oxidase activity (ceruloplasmin). Clin. Chem. 4:519, 1958.

[8] 8. O'REILLY, S. Problems in Wilson's disease. Neurology (Minneapolis) 17: 137, 1967.

[9] 9. O'REILLY, S.; POLLYCOVE, M.; TONO, M. & HERRADORA, L. Abnormalities of the physiology of copper in Wilson's disease: the internal kinetics of copper. Arch. Neurol. (Chicago) 24:481, 1971.

[10] 10. O'REILLY, S.; WEBER, P. M.; OSWALD, M. & SHIPLEY, L. Abnormalities of the physiology of copper in Wilson's disease: the excretion of copper. Arch. Neurol. (Chicago) 25:28, 1971.

[11] 11. OSBORN, S. & WALSHE, J. M. Copper uptake by the liver: study of a Wilson's disease family. In J. M. Walshe & J. N. Cumings Wilson's Disease, Some Current Concepts. Blackwell, Oxford, 1961, p. 141.

[12] 12. SASS-KORTSAK, A.; CHERNIAK, M.; GEIGER, D. W. & SLATER, R. J. Observations on ceruloplasmin in Wilson's disease. J. clin. Invest. 38:1672, 1959.

[13] 13. SCHEINBERG, I. H. & MORELL, A. G. Ceruloplasmin. In G. Eichhorn Inorganic Biochemistry. Elsevier, Amsterdam, 173, vol. 1, chapter 10, p. 306.

[14] 14. TRIP, J. A. J. Ceruloplasmin: Clinical and Experimental Investigations on Origin, Presence and Behavior of Fractions. Wolters-Noorhoff, Groningen, 1968.

[15] 15. WALSHE, J. M. The physiology of copper in man and its relation to Wilson's disease. Brain 90:149, 1967.

[16] 16. ZIMDAHL, W. T.; HYMAN, I. & COOK, E. D. Metabolism of copper in hepatolenticular degeneration. Neurology (Minneapolis) 3:569, 1953.