Alterações nucleares e nucleolares nas panencefalites subagudas esclerosantes

Alencar, Alexandre

doi:10.1590/S0004-282X1969000300001

Resumos

Relato de minucioso estudo das alterações nucleares e nucleolares encontradas nas chamadas panencefalites subagudas esclerosantes dos tipos Dawson (4 casos) e de Van Bogaert (três casos) e na panencefalite nodular de PettDöring (três casos), sendo demonstrada nestes processos mórbidos, pela primeira vez, a ocorrência de fenômenos da anisonucleolinose com extrusão de nucleolinos. Este tipo de alteração nucleolar foi encontrado mais freqüentemente no tipo Pette-Döring que nos tipos Dawson e Van Bogaert, sendo mais um argumento em favor da etiologia viral destes processos.

A study of nuclear and nucleolar alterations found in cases of subacute sclerosing leucoencephalitis of van Bogaert (three cases) and of Dawson type (four cases) and in nodular panencephalitis of Pette-Döring (three cases) is reported. In all these types of encephalites there was found anisonucleolinosis with extrusion of nucleolinus, alterations not yet reported in these precesses. These nucleolar changes were found more frequently in Pette-Döring than in Dawson and Van Bogaert types, being a strong argument favouring the viral aetiology of these diseases.

Alterações nucleares e nucleolares nas panencefalites subagudas esclerosantes

Subacute sclerosing panencephalitis: histological study of nuclear and nucleolar alterations

Alexandre Alencar

Chefe da Secção de Neuropatologia do Instituto de Neurologia da Universidade Federal do Rio de Janeiro (Prof. Deolindo Couto); Chefe da Secção de Anatomia Patológica do Instituto Oswaldo Cruz

RESUMO

Relato de minucioso estudo das alterações nucleares e nucleolares encontradas nas chamadas panencefalites subagudas esclerosantes dos tipos Dawson (4 casos) e de Van Bogaert (três casos) e na panencefalite nodular de PettDöring (três casos), sendo demonstrada nestes processos mórbidos, pela primeira vez, a ocorrência de fenômenos da anisonucleolinose com extrusão de nucleolinos. Este tipo de alteração nucleolar foi encontrado mais freqüentemente no tipo Pette-Döring que nos tipos Dawson e Van Bogaert, sendo mais um argumento em favor da etiologia viral destes processos.

SUMMARY

A study of nuclear and nucleolar alterations found in cases of subacute sclerosing leucoencephalitis of van Bogaert (three cases) and of Dawson type (four cases) and in nodular panencephalitis of Pette-Döring (three cases) is reported. In all these types of encephalites there was found anisonucleolinosis with extrusion of nucleolinus, alterations not yet reported in these precesses. These nucleolar changes were found more frequently in Pette-Döring than in Dawson and Van Bogaert types, being a strong argument favouring the viral aetiology of these diseases.

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

Instituto de Neurologia Av. Wenceslau Braz 95, Botafogo Rio de Janeiro, GB Brasil.

1. ALENCAR, A.; BROCK, M. & CAVALCANTI, J. T. S. Encefalites atípicas. J. bras. Neurol. Vol. 16, 1965 (em publicaçăo).
2. BARR, M. R. & BERTRAM, E. G. A morphological distinction between neurones of the male and the behaviour of the nucleolar satellite during accelerated nucleoprotein synthesis. Nature (London) 163:676, 1939.
3. BOGAERT, L. VAN Une leucoencéphalite sclérosante subaigue. J. Neurol. Neurosurg. & Psychiat. 8:101, 1945.
4. BOGAERT, L. VAN Sur une leucoencephalite sclérosante subaiguë (deuxičme mémoire). Rev. Neurol. 87:1, 1952.
5. BOGAERT, L. VAN Encephalitides. InEncephalitides: L. Van Bogaert, J. Hozay e A. Lőwenthal, editores. Elsevier Publishing Co., Amsterdam, 1981.
6. BOUTEILLE, M.; FONTAINE, C.; VEDRENNE, Cl. & DELAURE, J. Sur un cas d'encéphalite subaigue ŕ inclusions: étude anatomo-clinique. Rev. Neurol. 113:454, 1965.
7. BRACHET, J. The use of basic dyes and ribonuclease for the cytochemical detection of ribonucleic acid. Quart. J. Micr. Scien. 94:1, 1963.
8. DAYAN, A. D.; GORTLING, J. V. T.; GREAVES, J. L.; STEVENS, D. W. & WOODHOUSE, M. A. Evidence of a pseudomyxovirus in the brain in subacute sclerosing leucoencephalitis. Lancet 1, 7497:980, 1967.
9. DAWSON Jr., J. R. Cellular inclusions in cerebral lesions of lethargic encephalitis. Am. J. Path. 9:7, 1933.
10. DAWSON, Jr., J. R. Cellular inclusions in cerebral lesions of epidemic encephalitis: second report. Arch. Neurol. & Psychiat. 31:685, 1934.
11. ECONOMO, C. VON Encephalitis Lethargica: its Sequellae and Treatment. Oxford University Press, London, 1931.
12. GASPERSSON, T. O. Cell Growth and Cell Function. A Cytochemical Study. W. A. Norton & Co., New York, 1950.
13. HAGGAR, R. A. Behavior of the aceásory body of Cajal during axon reaction. J. comp. Neurol. 108:269, 1957.
14. HYDÉN, H. Protein and nucleotide metabolism in the nerve cell under different functional condictions. Symposia of the Soc. Exp. Biol. 1:150, 1947.
15. LOVE, R. Differences in the internal structure of nucleoli of diploid transformed or neoplastic cells in vitro.Exp. Cell. Res. 40:188, 1965.
16. LOVE, R. Anisonucleolinosis in Mammalian Cell Cultures. National Cancer Institute Monograph 23:167, 1966.
17. LOVE, R. & BHARADWAJ, T. P. Two types of ribonucleoproteins in the nucleolus of mammalian cells. Nature (London) 183:1453, 1959.
18. LOVE, R. & FERNANDES, M. V. Cytological and cytochemical studies of green monkey kidney cells infected in vitrowith simian virus 40. J. Cell Biol. 25:529, 1965.
19. LOVE, R. & LILES, R. H. Differentiation of nucleoproteins by inactivation of protein bound amino groups and staining with toluidine blue and ammonium molybdate. J. Histochem. Cytochem. 7:164, 1959.
20. LOVE, R. & RABOTTI, G. Studies of the cytochemistry of nucleoproteins: demonstration of deoxyribonucleic acid-ribonucleic acid complexes in mammalian cells. J. Histochem Cytochem. 11:603, 1963.
21. LOVE, R.; RABSON, A. S. & WILDY, P. Changes in the nucleolus of normal and neoplastic cells infected with riboviruses and deoxyriboviruses. Acta Unio Internationalis Contra Cancro 20:1384, 1964.
22. LOVE, R. & SUSKIND, R. G. Characterization of nine types of ribonucleprotein in the cell by the toluidine blue-molybdate stain. Ann. Histochem 6:437, 1962.
23. LOVE, R. & WALSH, R. J. Studies of the cytochemistry of nucleoproteins: improved staining methods with toluidine blue and ammonium molybdate. J. Histochem. Cytochem. 11:188, 1963.
24. LOVE, R. & WILDY, P. Cytochemical studies of the nucleoproteins of Helia cell infected with herpes virus. J. cell Biol. 17:237, 1963.
25. Measles and panencephalitis. Editorial. Brit. med. J. 189, 1968.
26. MOORE, K. L. The Sex Chromatin. W. B. Saunders Co., Philadelphia, London, 1966.
27. NAGEL, IT. Subacute sclerosing leucoencephalitis: ultrastructure of intranuclear and intracytoplasmic inclusions. Science 154:899, 1966.
28. PERIER, O. & VANDERHAEGHEN, J. J. Indications etiologiques apportées par la microscopie électronique dans certaines encéphalites humaines. Rev. Neurol. 115:250, 1965.
29. PETTE, H. & DÖRING, G. Über einheimische Panencephalomyelitis von Charakter der Encephalitis japonica. Dtsch. Z. Nervenheilk. 149:7, 1939.
30. SHAW, C. M.; BUCHAN, G. C. & COLDEVIN, B. C. Myxovirus as a possible etiologic agent in subacute inclusion body encephalitis. New England J. Med. 277:511, 1967.
31. SMITH, M. G.; LENNETTE, E. H. & REAME, H. R. Isolation of the virus of herpes simplex and the demonstration of intranuclear inclusions in acute encephalitis. Am. J. Path. 17:55, 1941.
32. SPIELMEYER, W. Histopathologie des Nervensystems. Julius Springer Verlag, Berlin, 1922.
33. THOMPSON, B. K.; HAGGAR, R. A. & BARR, M. L. The accessory body of Cajal in nerve cell nuclei of the cat. J. comp. Neurol. 108:253, 1957.
34. ZEMAN, W. Leucoéncéphalite sclérosante subaigüe et virus de la rougéole. Presse méd. 79:907, 1968.

Datas de Publicação

Publicação nesta coleção
23 Abr 2013
Data do Fascículo
Set 1969

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. ALENCAR, A.; BROCK, M. & CAVALCANTI, J. T. S. Encefalites atípicas. J. bras. Neurol. Vol. 16, 1965 (em publicaçăo).

[2] 2. BARR, M. R. & BERTRAM, E. G. A morphological distinction between neurones of the male and the behaviour of the nucleolar satellite during accelerated nucleoprotein synthesis. Nature (London) 163:676, 1939.

[3] 3. BOGAERT, L. VAN Une leucoencéphalite sclérosante subaigue. J. Neurol. Neurosurg. & Psychiat. 8:101, 1945.

[4] 4. BOGAERT, L. VAN Sur une leucoencephalite sclérosante subaiguë (deuxičme mémoire). Rev. Neurol. 87:1, 1952.

[5] 5. BOGAERT, L. VAN Encephalitides. InEncephalitides: L. Van Bogaert, J. Hozay e A. Lőwenthal, editores. Elsevier Publishing Co., Amsterdam, 1981.

[6] 6. BOUTEILLE, M.; FONTAINE, C.; VEDRENNE, Cl. & DELAURE, J. Sur un cas d'encéphalite subaigue ŕ inclusions: étude anatomo-clinique. Rev. Neurol. 113:454, 1965.

[7] 7. BRACHET, J. The use of basic dyes and ribonuclease for the cytochemical detection of ribonucleic acid. Quart. J. Micr. Scien. 94:1, 1963.

[8] 8. DAYAN, A. D.; GORTLING, J. V. T.; GREAVES, J. L.; STEVENS, D. W. & WOODHOUSE, M. A. Evidence of a pseudomyxovirus in the brain in subacute sclerosing leucoencephalitis. Lancet 1, 7497:980, 1967.

[9] 9. DAWSON Jr., J. R. Cellular inclusions in cerebral lesions of lethargic encephalitis. Am. J. Path. 9:7, 1933.

[10] 10. DAWSON, Jr., J. R. Cellular inclusions in cerebral lesions of epidemic encephalitis: second report. Arch. Neurol. & Psychiat. 31:685, 1934.

[11] 11. ECONOMO, C. VON Encephalitis Lethargica: its Sequellae and Treatment. Oxford University Press, London, 1931.

[12] 12. GASPERSSON, T. O. Cell Growth and Cell Function. A Cytochemical Study. W. A. Norton & Co., New York, 1950.

[13] 13. HAGGAR, R. A. Behavior of the aceásory body of Cajal during axon reaction. J. comp. Neurol. 108:269, 1957.

[14] 14. HYDÉN, H. Protein and nucleotide metabolism in the nerve cell under different functional condictions. Symposia of the Soc. Exp. Biol. 1:150, 1947.

[15] 15. LOVE, R. Differences in the internal structure of nucleoli of diploid transformed or neoplastic cells in vitro.Exp. Cell. Res. 40:188, 1965.

[16] 16. LOVE, R. Anisonucleolinosis in Mammalian Cell Cultures. National Cancer Institute Monograph 23:167, 1966.

[17] 17. LOVE, R. & BHARADWAJ, T. P. Two types of ribonucleoproteins in the nucleolus of mammalian cells. Nature (London) 183:1453, 1959.

[18] 18. LOVE, R. & FERNANDES, M. V. Cytological and cytochemical studies of green monkey kidney cells infected in vitrowith simian virus 40. J. Cell Biol. 25:529, 1965.

[19] 19. LOVE, R. & LILES, R. H. Differentiation of nucleoproteins by inactivation of protein bound amino groups and staining with toluidine blue and ammonium molybdate. J. Histochem. Cytochem. 7:164, 1959.

[20] 20. LOVE, R. & RABOTTI, G. Studies of the cytochemistry of nucleoproteins: demonstration of deoxyribonucleic acid-ribonucleic acid complexes in mammalian cells. J. Histochem Cytochem. 11:603, 1963.

[21] 21. LOVE, R.; RABSON, A. S. & WILDY, P. Changes in the nucleolus of normal and neoplastic cells infected with riboviruses and deoxyriboviruses. Acta Unio Internationalis Contra Cancro 20:1384, 1964.

[22] 22. LOVE, R. & SUSKIND, R. G. Characterization of nine types of ribonucleprotein in the cell by the toluidine blue-molybdate stain. Ann. Histochem 6:437, 1962.

[23] 23. LOVE, R. & WALSH, R. J. Studies of the cytochemistry of nucleoproteins: improved staining methods with toluidine blue and ammonium molybdate. J. Histochem. Cytochem. 11:188, 1963.

[24] 24. LOVE, R. & WILDY, P. Cytochemical studies of the nucleoproteins of Helia cell infected with herpes virus. J. cell Biol. 17:237, 1963.

[25] 25. Measles and panencephalitis. Editorial. Brit. med. J. 189, 1968.

[26] 26. MOORE, K. L. The Sex Chromatin. W. B. Saunders Co., Philadelphia, London, 1966.

[27] 27. NAGEL, IT. Subacute sclerosing leucoencephalitis: ultrastructure of intranuclear and intracytoplasmic inclusions. Science 154:899, 1966.

[28] 28. PERIER, O. & VANDERHAEGHEN, J. J. Indications etiologiques apportées par la microscopie électronique dans certaines encéphalites humaines. Rev. Neurol. 115:250, 1965.

[29] 29. PETTE, H. & DÖRING, G. Über einheimische Panencephalomyelitis von Charakter der Encephalitis japonica. Dtsch. Z. Nervenheilk. 149:7, 1939.

[30] 30. SHAW, C. M.; BUCHAN, G. C. & COLDEVIN, B. C. Myxovirus as a possible etiologic agent in subacute inclusion body encephalitis. New England J. Med. 277:511, 1967.

[31] 31. SMITH, M. G.; LENNETTE, E. H. & REAME, H. R. Isolation of the virus of herpes simplex and the demonstration of intranuclear inclusions in acute encephalitis. Am. J. Path. 17:55, 1941.

[32] 32. SPIELMEYER, W. Histopathologie des Nervensystems. Julius Springer Verlag, Berlin, 1922.

[33] 33. THOMPSON, B. K.; HAGGAR, R. A. & BARR, M. L. The accessory body of Cajal in nerve cell nuclei of the cat. J. comp. Neurol. 108:253, 1957.

[34] 34. ZEMAN, W. Leucoéncéphalite sclérosante subaigüe et virus de la rougéole. Presse méd. 79:907, 1968.