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Histoyathology of the nerve endings in the tuberculous laryngitis

The larynges of 16 patients who died in the course of severe pulmonary tuberculosis and of 4 normal subjects are studied. Impregnations were done by Boeke's method and sometimes by Cajal's reduced silver nitrate; stainings by hematoxylin-eosine and Gomori were also used. In the normal larynges the nerve endings were studied; free and plexual nerve endings were described and discussed; the author states that this latter pattern is of higher phylogenetical rank and allows better relationship between the nerve fiber and the protoplasm. In the pathological cases the stainings showed changes in the nerve endings and fibers; in the nerve endings hypertrophy with development of argentic balls and hyperplasia (buds and collaterals of the ending neuroma) are seen; nerve fibers are swollen, with nodosities, changes in the neurofibrils and loss of affinity for the silver salts; the lesions are more severe in the neighborhood of the tuberculous processes. When the laryngeal tuberculosis develops slowly, proliferative changes prevail in the nerve endings and fibers; when the evolution is rapid, the nerve fibers show a greater number of degenerative changes and the nerve endings go into lysis. The changes are not specific, as they can be detected in other diseases.


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