Bioactive derivatives obtained from lecanoric acid, a constituent of the lichen Parmotrema tinctorum (Nyl.) Hale (Parmeliaceae)

Bioactive derivatives obtained from lecanoric acid, a constituent of the lichen Parmotrema tinctorum (Nyl.) Hale (Parmeliaceae)

Alcir Teixeira Gomes^I; Neli K. Honda^{I, *}; Fernanda Mesquita Roese^I; Rozanna M. Muzzi^I; Maria Rita Marques^II

^IDepartamento de Química, Universidade Federal de Mato Grosso do Sul, 79070-900, Campo Grande, MS

^IIDepartamento de Morfofisiologia, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil

ABSTRACT

With the aim of obtaining new compounds with potential antifungal activity, lecanoric acid, a chemical constituent of the lichen Parmotrema tinctorum and its derivatives prepared from structural modification were tested against the fungus Cladosporium sphaerospermum, by employing the bioautographic method. Activity of the derivatives ranged from 10- to 1-μg concentrations. Results demonstrated this series of compounds to have potent fungitoxic activity.

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Acknowledgements

Financial support from CNPq-PROPP-UFMS and CNPq is gratefully acknowledged. Thanks are due to Dr. Mariana Fleig for the identification of the lichen. A.T.G. also wishes to thank CAPES for the grant provided.

References

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Publication Dates

• Publication in this collection
  05 Oct 2009
• Date of issue
  2002