WISP1 rs2929970 |
Susceptibility to spinal OA in woman |
Urano et al.2525 Urano T, Narusawa K, Hosoi T, Ouchi Y, Nakamura T, Inoue S. Association of a single nucleotide polymorphism in the WISP1 gene with spinal osteoarthritis in postmenopausal Japanese women. J Bone Miner Metab. 2007;25:253-8.
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RAGE rs2070600 |
Susceptibility to knee OA |
Han et al.2626 Han Z, Liu Q, Sun C, Li Y. The interaction between obesity and RAGE polymorphisms on the risk of knee osteoarthritis in Chinese population. Cell Physiol Biochem. 2012;30:898-904.
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DVWA rs7639618 |
Susceptibility to knee OA |
Zhang et al.2727 Zhang R, Yao J, Xu P, Ji B, Voegeli G, Hou W, et al. Association between genetic variants of DVWA and osteoarthritis of the knee and hip: a comprehensive meta-analysis. Int J Clin Exp Med. 2015;8:9430-7.
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ACE rs4343, rs4362 |
Susceptibility to knee OA |
Qing et al.2828 Qing Z, Ye J. Association between ACE polymorphisms and osteoarthritis susceptibility. Int J Clin Exp Pathol. 2015;8:7391-6.
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MATN3 rs8176070 |
Susceptibility to OA |
Gu et al.2929 Gu J, Rong J, Guan F, Jiang L, Tao S, Guan G, et al. MATN3 gene polymorphism is associated with osteoarthritis in Chinese han population: a community-based case–control study. Scientific World J. 2012;2012:656084.
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DIO2 rs225014 |
Susceptibility to OA |
Meulenbelt et al.3030 Meulenbelt I, Min J, Bos S, Riyazi N, Houwing J, Slagboom E, et al. Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis. Hum Mol Genet. 2008;17:1867-75.
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ADAMTS14 rs4747096 |
knee OA in woman (Thai population) |
Poonpet et al.3131 Poonpet T, Honsawek S, Tammachote N, Kanitnate S, Tammachote R. ADAMTS14 gene polymorphism associated with knee osteoarthritis in Thai women. Genet Mol Res. 2013;12:5301-9.
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ADAM12 rs1871054 |
Increased risk of OA |
Wang et al.3232 Wang L, Guo L, Tian F, Hao R, Yang T. Analysis of single nucleotide polymorphisms within ADAM12 and risk of knee osteoarthritis in a Chinese Han population. Biomed Res Int. 2015;2015:518643.; Kerna et al.3333 Kerna I, Kisand K, Tamm AE, Kumm J, Tamm AO. Two single-nucleotide polymorphisms in ADAM12 gene are associated with early and late radiographic knee osteoarthritis in Estonian population. Arthritis. 2013;2013:878126.
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HIF1A rs11549465 |
Protective role in the loss of articular cartilage |
Fernández et al.3434 Fernández-Torres J, Hernández-Díaz C, Espinosa-Morales R, Camacho-Galindo J, Galindo-Sevilla Ndel C, López-Macay A, et al. Polymorphic variation of hypoxia inducible factor-1 A (HIF1A) gene might contribute to the development of knee osteoarthritis: a pilot study. BMC Musculoskelet Disord. 2015;16:218.
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IL6 rs1800796 |
Protective factor for hip and knee OA in the elderly |
Fernandes et al.3535 Fernandes MT, Fernandes KB, Marquez AS, Cólus IM, Souza MF, Santos JP, et al. Association of interleukin-6 gene polymorphism (rs1800796) with severity and functional status of osteoarthritis in elderly individuals. Cytokine. 2015;75:316-20.
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IL16 rs11556218, rs4072111, rs4778889 |
Decreased knee OA risk |
Luo et al.3636 Luo SX, Li S, Zhang XH, Zhang JJ, Long GH, Dong GF, et al. Genetic polymorphisms of interleukin-16 and risk of knee osteoarthritis. PLoS One. 2015;10:e0123442.; Liu et al.3737 Liu Z, Ma L, Qiu S, Jia T. Genetic polymorphisms of interleukin-16 are associated with susceptibility to primary knee osteoarthritis. Int J Clin Exp Med. 2015;8:1401-1405, eCollection 2015.
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GDF5 rs143383 |
Protective factor for knee OA |
Pan et al.3838 Pan F, Tian J, Winzenberg T, Ding C. Association between GDF5 rs143383 polymorphism and knee osteoarthritis: an updated meta-analysis based on 23,995 subjects. BMC Musculoskelet Disord. 2014;15:404.; Tawonsawatruk et al.3939 Tawonsawatruk T, Changthong T, Pingsuthiwong S, Trachoo O, Saura T, Wajanavisit W. A genetic association study between growth differentiation factor (GDF5) polymorphism and knee osteoarthritis in Thai population. J Orthopaed Surg. 2011;Res6:2-5.
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