Lage et al., (2019)(1111 Lage MLC, Carvalho AL, Ventura PA, Taguchi TB, Fernandes AS, Pinho SF, et al. Clinical, neuroimaging, and neurophysiological findings in children with microcephaly related to congenital Zika Virus Infection. Int J Environ Res Public Health. 2019;16(3):309. doi: 10.3390/ijerph16030309
https://doi.org/10.3390/ijerph16030309...
)
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Describe the clinical, neuroimaging and neurophysiological findings of children with congenital microcephaly diagnosed at birth, associated with ZIKV congenital infection. |
Brazil |
102 newborns with microcephaly |
Severe microcephaly (54.9%), cerebral malformations (100%); cerebral atrophy (92.1%), ventriculomegaly (92.1%), malformation of cortical development (85.1%) and subcortical calcifications (80.2%); abnormalities in neurological examinations (97.0%), seizures (56.3%) and arthrogryposis (10.8%); hearing loss (17.3%) and visual impairment (14.1%) of breastfeeding infants. |
Rocha et al., (2019)(1212 Rocha SGMO, Correia LL, Da Cunha AJLA, Rocha HAL, Leite ÁM, Campos JS, et al. Zika Virus Infection and Microcephaly: a case-control study in Brazil. Ann Glob. Health. 2019;85(1):116. doi: 10.5334/aogh.2394
https://doi.org/10.5334/aogh.2394...
)
|
Identify factors associated with the diagnosis of microcephaly in newborns, including zika virus infection. |
Brazil |
58 children with microcephaly and 116 controls |
The chance of having a newborn with microcephaly was 14 times higher among mothers who had infection with zika virus (p < 0,001). |
Trigueiroet al., (2019)(1313 Trigueiro SA, Neves BF, Aguiar MSB, Araujo JSS. Correlation between cephalic circumference at birth and ocular alterations in patients with microcephaly potentially associated with Zika Virus infection. Rev Assoc Med Bras. 2019;65(6):909-13. doi 10.1590/1806-9282.65.6.909
https://doi.org/0.1590/1806-9282.65.6.90...
)
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Describe the profile of children with microcephaly, whose mothers had zika infection during pregnancy. |
Brazil |
20 newborns with microcephaly |
Eye alterations (70%) and macular atrophy (30%). Eye alterations varied from normal to paleness and hypoplasia of the optic nerve, dispersion of the pigment epithelium of the retina in the macular region and chorioretinal macular atrophy. |
Portnoi et al., (2019)(1414 Baran LCP, Costa MF, Vidal KS, Damico FM, Barboni MTS, Lima DS, et al. Alterations in visual acuity and visual development in infants 1-24 months old either exposed to or infected by Zika virus during gestation, with and without microcephaly. J AAPOS. 2019;23(4):215. doi: 10.1016/j.jaapos.2019.03.005
https://doi.org/10.1016/j.jaapos.2019.03...
)
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Assess visual acuity and development of visual acuity in children exposed to the zika virus in pregnancy. |
Brazil |
23 exposed children and 24 infected children |
Abnormal visual acuity was found in 5 out of 24 children infected with ZIKV. Of the four children with microcephaly, two had loss of visual acuity and one had abnormal result in the retina examination. |
Einspieler et al., (2019)(1515 Einspieler C, Utsch F, Brasil P, Aizawa CYP, Peyton C, Hasue RH, et al. Association of infants exposed to prenatal Zika Virus Infection with their clinical, neurologic, and developmental status evaluated via the general movement assessment tool. JAMA. 2019;2(1):1-13. doi: 10.1001/jamanetworkopen.2018.7235
https://doi.org/10.1001/jamanetworkopen....
)
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Perform general movement assessment among children from 9 to 20 weeks of age; and assess neurological development at 12 months of age in children exposed to prenatal care to ZIKV and in paired controls. |
Brazil /
Australia |
111 exposed children and 333 control children |
Of the exposed children, 50.4% had abnormal neurological development and no microcephaly. Of the ten children exposed to ZIKV without microcephaly at 12 months of age, seven had no restless movements. Children with microcephaly had bilateral spastic cerebral palsy; none had normal movements. |
Venturaet al., (2019)(1616 Ventura PA, Lage MLC, Carvalho AL, Fernandes AS, Taguchi TB, Nascimento-Carvalho CM. Early gross motor development among brazilian children with microcephaly born right after Zika Virus Infection outbreak. J Dev Behav Pediatr. 2019;41(2):134-40. doi: 10.1097/dbp.0000000000000722
https://doi.org/10.1097/dbp.000000000000...
)
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To evaluate the gross motor development of children with supposedly congenital zika virus infection in the first two years of life. |
Brazil |
77 children (ages 11, 18 and 24 months) |
All children evaluated in the study showed clinical diagnosis of cerebral palsy (PC) at 2 years of age. Seventy-four (96.1%) showed motor skills similar to children aged 4 months or less, and 73 (94.8%) children had quadriplegia. No significant difference (p = 0.076) was found between 18 and 24 months. |
Cortes et al., (2018)(1717 Cortes MS, Rivera AM, Yepez M, Guimaraes CV, Yunes ID, Zarutskie A, et al. Clinical assessment and brain findings in a cohort of mothers, fetuses and infants infected with ZIKA virus. Am J Obstet Gynecol. 2018;218(4):440. doi: 10.1016/j.ajog.2018.01.012
https://doi.org/10.1016/j.ajog.2018.01.0...
)
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To evaluate the prevalence of microcephaly and the frequency of abnormalities based on imaging examinations; and to obtain additional information from placental and fetal histopathological evaluations and postnatal clinical evaluations. |
Colombia |
12 newborns |
The main abnormalities found in the MRI examination were (11/12; 91.7%) calcifications and ventriculomegaly, abnormalities of the corpus callosum (12/12; 100%), cortical malformations (8/9; 89%). At birth, most of the affected neonates (55.6%-77.8%) presented measurements of PC > 3 and standard deviation below medium. |
|
Subissi et al., (2018)(55 Subissi L, Dub T, Besnard M, Mariteragi-Helle T, Nhan T, Lutringer-Magnin D, et al. Zika virus infection during pregnancy and effects on early childhood development, French Polynesia, 2013-2016. Emerging Infect Dis. 2018;24(10):1850-8. doi 10.3201/eid2410.172079)
|
Determine the temporal association of a cluster of congenital defects with zika virus infection |
French Polynesia |
21 cases and 102 controls |
Microcephaly (33.3%) and brain stem dysfunction characterized by inability to suck and swallow (23.8%), among other congenital defects in the CNS (42.8%). Ventriculomegaly (28%) and arthrogryposis (14,2%). |
Tsui et al., (2018)(1818 Tsui I, Moreira MEL, Rossetto JD, Vasconcelos Z, Gaw SL, Neves LM, et al. Eye findings in infants with suspected or confirmed antenatal Zika Virus exposure. Pediatrics. 2018;142(4):e20181104. doi: 10.1542/peds.2018-1104
https://doi.org/10.1542/peds.2018-1104...
)
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Characterize the ophthalmic manifestations of confirmed or suspected prenatal exposure to zika virus (ZIKV) |
Brazil |
224 breastfeeding infants |
Abnormalities in the CNS (40.2%), including microcephaly (27.7%). Eye abnormalities were found in 49 of 90 infants (54.4%) and correlated with the presence of CNS findings (odds ratio 14.9; 95% CI: 7.3-30.3; p < 0.0001). Of the children without microcephaly or other abnormalities in the CNS, 3.7% had ocular abnormalities. |
Zin et al., (2018)(1919 Zin AA, Tsui I, Rossetto JD, Gaw SL, Neves LM, Zin OA, et al. Visual function in infants with antenatal Zika virus exposure. J AAPOS. 2018;22(6):452-6. doi: 10.1016/j.jaapos.2018.07.352
https://doi.org/10.1016/j.jaapos.2018.07...
)
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To evaluate visual function in breastfeeding infants with confirmed or suspected prenatal exposure to infecction by ZIKV during the outbreak of zika. |
Brazil |
173 children with microcephaly |
Of the children evaluated, 49.1% presented abnormal findings in the CNS; 35.8%, microcephaly; and 13.3%, other abnormalities in the CNS without microcephaly. Abnormal visual function was present in 30% of children; eye alterations in 26%; nystagmus in 15,6%. |
Hoen et al., (2018)(2020 Hoen B, Schaub B, Funk AL, Ardillon V, Boullard M, Cabie A, et al. Pregnancy outcomes after ZIKV infection in French territories in the Americas. N Engl J Med. 2018;378(11):985-94. doi: 10.1056/NEJMoa1709481
https://doi.org/10.1056/NEJMoa1709481...
)
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Estimate the risk among pregnant women with symptomatic ZIKV infection. |
French Guiana,
Guadeloupe and Martinique |
546 pregnant women with ZIKV |
Neurological and ocular abnormalities associated with ZIKV infection were observed in 39 newborns (7.0%; CI: 95%, 5.0 to 9.5). Microcephaly was detected in 32 fetuses and newborns (5.8%): in 1.6%, it was severe; in 1.6%, it was moderately disproportionate; and in 2.5%, it was moderately proportional. Severe microcephaly or other brain abnormalities were observed in 17 fetuses and newborns (3,1%). |
Pinato et al., (2018)(2121 Pinato L, Ribeiro EM, Leite RFP, Lopes TF, Pessoa ALS, Campos LMG, et al. Sleep findings in Brazilian children with congenital Zika syndrome. Sleep. 2018;41(3). doi: 10.1093/sleep/zsy009
https://doi.org/10.1093/sleep/zsy009...
)
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Investigate the sleep characteristics of newborns/breastfeeding infants (88 with CZS and 48 with healthy development, age, and paired sex) using the Child Sleep Questionnaire. |
Brazil |
136 newborns and infants |
Of children with CZS, 34.1% had poor sleep; 3.5% had more than three night awakenings; 15% were awake at night for more than an hour; and 24% had less than nine hours of total sleep time. The average time to start sleeping at night was later for the CZS group. When the duration of night sleep was analyzed, 51% of the CZS group and 20.8% of the healthy group had less than nine hours of sleep. |
França et al., (2018)(2222 França TLB, Medeiros WR, Souza NL, Longo E, Pereira SA, Oliveira França TB. Growth and development of children with microcephaly associated with congenital zika virus syndrome in Brazil. Int J Environ Res Public Health. 2018;15(9):1990. doi: 10.3390/ijerph15091990
https://doi.org/10.3390/ijerph15091990...
)
|
To evaluate the growth and development of children with CZS compared to healthy children. |
Brazil |
Children CZS
(n = 08) / Children with no CZS (n = 16) |
The average growth rate was lower in the group of children with CZS (p < 0.05) in weight and cephalic perimeter measurements at 20.5 months of age. There was a significant difference (p = 0.000) in cognitive and motor performance between the groups. |
Wheeler AC, (2018)(2323 Wheeler AC. Development of infants with congenital zika syndrome: what do we know and what can we expect? Pediatrics. 2018;141:154-60. doi: 10.1542/peds.2017-2038D
https://doi.org/10.1542/peds.2017-2038D...
)
|
Describe the developmental profile of breastfeeding infants with CZS in skills achieved at 16 months of age. |
Brazil |
52 children with CZS |
Of the children, 81% had severe hypertonia and multiple contractures; 83.8% had visual impairment, of which 41.9% had severe impairment; 17% had hearing impairment; 11% had arthrogryposis. No child showed age-appropriate motor skills. Only one (1.9%) was able to sit without support or walk without support. About 50% did not hold a small object in their hands and was unable to drink liquid in a glass. |
Orofino et al., (2018)(2424 Orofino DHG, Passos SRL, Oliveira RVC, Farias CVB, Leite M, Pone SM, et al. Cardiac findings in infants with in utero exposure to Zika virus- a cross sectional study. PLoS Negl Trop Dis. 2018;12(3):e0006362. doi: 10.1371/journal.pntd.0006362
https://doi.org/10.1371/journal.pntd.000...
)
|
Report echocardiographic (ECO) findings in infants with laboratory confirmed prenatal exposure to ZIKV. |
Brazil |
120 children with prenatal exposure to ZIKV |
Of the children, 40% presented alterations observed in echocardiography, while 10.8% had heart defects such as interatrial communication, ventricular interatrial communication, and persistence of the ductus arteriosus. The frequency of heart defects was observed in newborns that were exposed in the 2nd trimester of pregnancy or in those in which the image examination of the (CNS) was altered in the postnatal period or in premature. |
Kikuti et al., (2016)(2525 Kikuti M, Cardoso CW, Prates APB, Paploski IAD, Kitron U, Reis MG, et al. Congenital brain abnormalities during a Zika virus epidemic in Salvador, Brazil, April 2015 to July 2016. Euro Surveill. 2018;23(45):1-10. doi: 10.2807/1560-7917.es.2018.23.45.1700757
https://doi.org/10.2807/1560-7917.es.201...
)
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Describe clinical and epidemiological aspects of the outbreak of congenital brain abnormalities; and assess the accuracy of different screening criteria of the cephalic perimeter |
Brazil |
365 newborns |
Congenital brain abnormalities (45.5%), intracranial calcifications and ventriculomegaly (86,1%). |
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